BRUSSELS, February 18, 2011 /PRNewswire/ -- The European Commission has just announced its decision to ban the fragrance material Musk xylene under the new European Chemicals Legislation REACH, bringing EU regulations in line with the global IFRA Standards.
The International Fragrance Association (IFRA) voluntarily banned Musk xylene through the IFRA Standards, part of the fragrance industry's global self-regulatory program contained in the IFRA Code of Practice.
THE SYNTHETIC fragrance musk ketone has been correctly declared a carcinogen with the same potential dangers to consumers as musk xylene
, a European Commission committee has concluded.
From 1995 to 2000, the total worldwide usage declined from 300 tons to 200 tons for musk xylene and musk ketone combined.
068 Abbreviations: MK, musk ketone; MX, musk xylene.
Even 24 hours after contact with the nitromusk called musk xylene
or the polycyclic musks branded galaxolide and tonalide, mussel tissues absorbed and retained significantly more rhodamine B than usual.
One type, musk xylene
, has been shown to cause cancer in mice.
These indirect and long-term toxicity effects are of particular concern because these chemicals are stable and bioaccumulate; for example, musk xylene has a half-life of 70 days in human tissue (Riedel and Dekant 1999).
Biotransformation and toxicokinetics of musk xylene in humans.
Efflux transport remained compromised 48 hours after exposure in tissue treated with certain commonly used compounds: musk xylene
, musk ketone, Galaxolide, and Celestolide.
(MX) is the most common nitromusk, but use was discontinued in Japan and a voluntary ban is in force in Germany (Kafferlein et al.
As in most cases, the "other chemical" category contains a variety of chemicals ranging from contemporary pesticides, polycyclic aromatic hydrocarbons, nicotine, ethanol, phthalates, musk xylenes
, and phytoestrogens, such as genestein.