mutation hot spot

mutation hot spot

[myü¦tā·shən ′hät ‚spöt]
(cell and molecular biology)
Any locus in the deoxyribonucleic acid sequence or on a chromosome where mutations or aberrations occur preferentially.
References in periodicals archive ?
Because Gn and Gc are major immunogens of orthobunyaviruses (10), the mutation hot spot was supposed to be involved in immune evasion mechanisms and/or adaption of the cell tropism within the individual host (7,9).
Mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-syndrome.
Based on the findings from these patients, they then performed targeted sequencing of suspected mutation hot spots in another 71 patients.
For such mutation hot spots, pyrosequencing provides the possibility to design a nucleotide dispensation order that increases the sensitivity of detection in combination with identification of all the relevant mutation variants.