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mutator phenotype

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mutator phenotype [¦myü‚tād·ər ′fēn·ə‚tīp]
(genetics)
The loss of function of one gene, such as one for the repair of damaged deoxyribonucleic acid, that greatly increases the mutation rates at other loci.


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The failure to show mutator phenotypes in Beijing/W strains suggests that this role may have been transient (10,11).
Studies of hereditary tumors of the colorectum have identified 2 major pathways by which CRCs develop--the suppressor gene pathway and the mutator phenotype pathway.
On the other hand, in Mi smegmatis, the abrogation of the Ung activity leads not only to increased mutator phenotype but also to growth inhibition by reactive nitrogen intermediates (7).
 
 
 
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