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myasthenia gravis |
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myasthenia gravis (mīəsthē`nēə grä`vĭs), chronic disorder of the muscles characterized by weakness and a tendency to tire easily. It is caused by an autoimmune attack on the acetylcholine receptor of the post synaptic neuromuscular junction. The initiating event leading to antibody production is unknown. The disease is most common between the ages of 20 and 40 and more frequent in women. The muscles of the neck, throat, lips, tongue, face, and eyes are primarily involved. Exertion quickly brings on difficulty in swallowing, chewing, and talking. The eyelids may droop, and there are visual disorders. Myasthenia gravis is transmitted passively to fetuses from infected mothers, a syndrome call neonatal myasthenia. Congenital myasthenia is a rare autosomal recessive disorder of neuromuscular transmission beginning in childhood, usually with ophthalmoplegia. Life-threatening myasthenic crisis, in which the diaphragm is affected and the patient has respiratory failure, occurs in 10% of the patients. Treatment of the disease includes the use of cholinesterase inhibitors, thymectomy, corticosteroids, and immunosuppressive agents and plasmapheresis (see apheresis apheresis (əfĕr`əsĭs), or hemapheresis ..... Click the link for more information. ). Prolonged rest is likely to restore some of the muscle function; restricted activity at all times and complete rest during periods of aggravation of the illness are necessary. myasthenia gravisChronic autoimmune disease causing muscle weakness. Autoantibodies block the response of muscle cells to acetylcholine. Muscles weaken with repeated use but regain their strength after rest. The pattern varies, but usually muscles used in eye movements, facial expressions, chewing, swallowing, and respiration are affected first, then neck, trunk, and limb muscles. Severe cases impede breathing. Anticholinesterase drugs stimulate nerve-impulse transmission, and corticosteroids may help. Removal of the thymus has improved severe cases. Remission lasting several years may occur. |
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Aspreva Pharmaceuticals Corporation (NASDAQ: ASPV; TSX: ASV), an emerging pharmaceutical company focused on increasing the pool of evidence-based medicines available for patients living with less common diseases today announced that based on a preliminary review of the data, CellCept(R) (mycophenolate mofetil or MMF) in treating myasthenia gravis (MG) failed to meet both primary and secondary endpoints in its phase III trial. The agent is now available for the treatment of generalized myasthenia gravis. The working diagnosis is myasthenia gravis, although there is no response to edrophonium and nystagmus is not common in myasthenia. |
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