myasthenia gravis


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myasthenia gravis

(mīəsthē`nēə grä`vĭs), chronic disorder of the muscles characterized by weakness and a tendency to tire easily. It is caused by an autoimmune attack on the acetylcholine receptor of the post synaptic neuromuscular junction. The initiating event leading to antibody production is unknown. The disease is most common between the ages of 20 and 40 and more frequent in women. The muscles of the neck, throat, lips, tongue, face, and eyes are primarily involved. Exertion quickly brings on difficulty in swallowing, chewing, and talking. The eyelids may droop, and there are visual disorders. Myasthenia gravis is transmitted passively to fetuses from infected mothers, a syndrome call neonatal myasthenia. Congenital myasthenia is a rare autosomal recessive disorder of neuromuscular transmission beginning in childhood, usually with ophthalmoplegia. Life-threatening myasthenic crisis, in which the diaphragm is affected and the patient has respiratory failure, occurs in 10% of the patients. Treatment of the disease includes the use of cholinesterase inhibitors, thymectomy, corticosteroids, and immunosuppressive agents and plasmapheresis (see apheresisapheresis
, or hemapheresis
, any procedure in which blood is drawn from a donor or patient and a component (platelets, plasma, or white blood cells) is separated out, the remaining blood components being returned to the body.
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). Prolonged rest is likely to restore some of the muscle function; restricted activity at all times and complete rest during periods of aggravation of the illness are necessary.

myasthenia gravis

[‚mī·əs·thēn·ē·ə ′grav·əs]
(medicine)
A muscle disorder of unknown etiology characterized by varying degrees of weakness and excessive fatigability of voluntary muscle.
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Appearance of Systemic Lupus Erythematosus in Patients with Myasthenia Gravis following Thymectomy: Two Case Reports.
Predictive value of single-fiber electromyography in the extensor digitorum communis muscle of patients with ocular myasthenia gravis : A retrospective study.
Incidence of seropositive myasthenia gravis in Cape Town and South Africa.
Respective role of thymusand muscle in autoimmune myasthenia gravis.
Neonatal myasthenia gravis in the infant of a myasthenic mother in remission.
Keywords: anesthesia, cardiac surgery, cisatracurium, muscle relaxants, myasthenia gravis
He is raising money for the charity myaware, formerly the Myasthenia Gravis Association, which supports people with various forms of the littleknown condition.
These data, combined with physical examination, confirmed the diagnosis of myasthenia gravis.