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Muscular weakness.



(asthenic bulbar paralysis, asthenic ophthalmoplegia, pseudobulbar paralysis, Erb-Goldflam disease), a neuromuscular disease characterized by the pathological, rapid fatigability of striated muscles.

The onset of myasthenia usually occurs between the ages of 20 and 40 years; women are more frequently affected, Autoimmune processes play a part in the development of the disease; antibodies have been discovered in muscle tissue and in the thymus gland. The muscles of the eyelids are often affected and there is ptosis, which varies in degree during the day; the masticatory muscles are affected, swallowing is disrupted, and the gait changes. Treatment includes anticholinesterase preparations, vitamins (especially B-group), general restorative treatment, and sometimes the removal of the thymus gland.


Lobzin, V. S. Miasteniia. Leningrad, 1960.
Shefer, D. G. Gipotalamicheskie (dientsefal’nye) sindromy, 2nd ed. Moscow, 1971.
References in periodicals archive ?
The Lambert-Eaton myasthenic syndrome 1988-2008: a clinical picture in 97 patients.
Myasthenic crisis represents a rapidly progressive decrease in the muscle strength which leads to respiratory failure and life-threatening conditions.
Neonatal myasthenia gravis in the infant of a myasthenic mother in remission.
Therefore, myasthenic patients are sensitive to nondepolarizing muscle relaxants (Baraka, 1992), including cisatracurium (Baraka, Siddik, & Kawkabani, 1999), and requirements for them during anesthesia are patient dependent (Baraka et al.
The ultra-rare diseases category includes Duchenne's muscular dystrophy (DMD), molybdenum cofactor deficiency (MoDC) type A, lysosomal acid lipase (LAL) deficiency, sporadic inclusion body myositis (sIBM), epidermal bulbosa (EB), Lambert-Eaton myasthenic syndrome (LEMS) and hypothosphatasia.
Among specific topics are histological and histochemical stains and reactions, how to read a biopsy, muscular distrophies and allied disorders, congenital myopathies and related disorders, myopathies associated with systemic disorders and aging, myasthenic syndromes, and toxic and drug-induced myopathies.
Skeletal and respiratory muscles can also be affected, placing the patient at risk of respiratory distress during a myasthenic crisis.
Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition.
Also last month Catalyst Pharmaceutical Partners received the designation for Firdapase to treat Lambert-Eaton myasthenic syndrome, a rare autoimmune disorder.
SCC lung cancer (SCLC) has been associated with paraneoplastic syndromes, such as hyponatremia, Cushing's Syndrome, Lambert-Eaton myasthenic syndrome, neuropathy, hypophosphatemia, hypercalcemia, and nephrotic syndrome.
In accordance with the cholinergic hypothesis, the present study examined the emotional functioning of myasthenic patients with respect to two components of theory of mind: the ability to interpret different emotions expressed on one's face and empathy.