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Muscular weakness.



(asthenic bulbar paralysis, asthenic ophthalmoplegia, pseudobulbar paralysis, Erb-Goldflam disease), a neuromuscular disease characterized by the pathological, rapid fatigability of striated muscles.

The onset of myasthenia usually occurs between the ages of 20 and 40 years; women are more frequently affected, Autoimmune processes play a part in the development of the disease; antibodies have been discovered in muscle tissue and in the thymus gland. The muscles of the eyelids are often affected and there is ptosis, which varies in degree during the day; the masticatory muscles are affected, swallowing is disrupted, and the gait changes. Treatment includes anticholinesterase preparations, vitamins (especially B-group), general restorative treatment, and sometimes the removal of the thymus gland.


Lobzin, V. S. Miasteniia. Leningrad, 1960.
Shefer, D. G. Gipotalamicheskie (dientsefal’nye) sindromy, 2nd ed. Moscow, 1971.
References in periodicals archive ?
The patients received routine myasthenic drugs on the morning of surgery (Table 1).
Diagnosis and treatment of Lambert-Eaton myasthenic syndrome.
For reasons not fully understood, the immune system in myasthenic patients produces antibodies against the receptors on which they are blocked, preventing binding and action.
The BioMarin medicine FirDapse - currently licensed for use in patients with Lambert-Eaton Myasthenic Syndrome - costs between pounds 40,000 and pounds 70,000 per patient a year, according to the Muscular Dystrophy Campaign.
Contributions cover acute neuropathies, chronic inflammatory demyelinating neuropathy and its variants, nonsystemic vasculitic neuropathy, dysimmune neuropathy, autoimmune autonomic ganglionopathy, myasthenia gravis with anti-acetylcholine receptor antibodies, muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis, Lambert-Eaton myasthenic syndrome, idiopathic inflammatory myopathies, and stiff person syndrome.
About 10% of MG patients develop a life threatening weakness of the respiratory muscles needed for breathing, a condition called myasthenic crisis.
Newsom-Davis J (2003): Therapy in Myasthenia Gravis and Lambert-Easton Myasthenic Syndrome.
Blalock removed the thymus gland from a myasthenic patient, who had a thymoma, and noted that the symptoms of myasthenia gravis dissipated.
The patient in whom this mutation was traced is a 20-year-old woman diagnosed with congenital myasthenic syndrome.
org 2,8 MYASTHENIC SYNDROME OF LAMBERT-EATON See: Charcot-Marie-Tooth Disease MYELIN DISORDERS See also: Leukodystrophy, The Canadian Myelin Research Initiative c/o Julie and Wayne Simmons 4330 Spinningdale Ct.
Some of the disorders affect skeletal muscle or the neuromuscular junction, such as hypokalemic periodic paralysis (HypoKPP) and LambertEaton myasthenic syndrome (LEMS).