They found that when fibrinogen (a blood-clotting protein) leaks into the central nervous system, it stops brain cells from producing myelin
and, as a result, prevents repair.
This new research has uncovered beneficial effects of immune cells in myelin
repair that have the potential to reverse myelin
Based in Boston, Myelin
is comprised of five companies.
Studying interactions among oligodendrocytes as well as the cells' reactions to various drugs may lead to improved therapies for multiple sclerosis, a disease caused by the destruction of myelin
The approach Sim and his colleagues took was to first characterize the molecular pathways that govern the differentiation of human oligodendrocyte progenitor cells, and then identify drug candidates that would promote differentiation and myelin
-producing cells called oligodendrocytes (OLs) recognise the repeating signal and wrap myelin
around the active circuit wiring.
For more information please contact: The Myelin
Project at info@myelin
What we know is that the adult human brain has the ability to repair myelin
," says Bruce Trapp, PhD, chair of the Department of Neurosciences at the Lerner Research Institute, part of the Cleveland Clinic.
On the other hand, when piglets are born, most of their myelin
production has already taken place, he adds.
Researchers have now proposed an easier process that involves nanoparticles to deliver myelin
For the first time, we have evidence that transplanted neural stem cells are able to produce new myelin
in patients with a severe myelination disease," Nalin Gupta, M.
Damage to myelin
can cause the symptoms of MS but there are currently no treatments to repair it.