are less than 5% of all cells, and maturing granulocytes are readily identified.
Blastic type is composed predominantly of myeloblasts
, immature type is composed of myeloblasts
and promyelocytes, differentiated type is composed of more promyelocytes and later stages of maturation(8).
Histologic examination of the spleen indicated a massive intravascular and extravascular accumulation of myeloblasts
with a variable proportion of promyelocytes and myelocytes in the red pulp of the spleen.
GMPs are also a sort of elite cells for cancer, as animals in which C/EBPa is removed become resistant to the development of acute myeloblastic leukemia since their myeloblasts
are unable to respond to oncogenes required for tumor formation.
Promyelocytes and myeloblasts
are not observed (Wright stain, 1000x).
The first, also called erythroleukemia, involves myeloblasts
and rubriblasts (BENNETT et al.
Myeloid sarcoma, also known as chloroma, extramedullary myeloid tumor or granulocytic sarcoma, is an extramedullary tumor mass consisting of immature myeloid cells and/or myeloblasts
The published photomicrographs reveal myeloblasts
with heavy granulations but no faggot cells or nuclear features of M3, although the report mentions "faggots" and/or Auer rods in three of four cases.
sup], Increased production of cytokines and expression of adhesion markers such as intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and selectin by endothelial cells enables myeloblasts
to recruit additional myeloblasts
Because after a first cycle of induction with idarubicin + cytarabine (3+7) she had 25-38% peroxidazo-positive myeloblasts
in bone marrow, she received a second cycle of induction of the same type.
When considered primary internal malignancies of these patients, 6 patients were diagnosed with gastrointestinal malignancy, 4--with lung cancer, 4--with breast cancer, 3--with malignant melanoma, 1--with Ewing's sarcoma, 1--with acute myeloblasts
leukemia and 1 patient was diagnosed with prostatic cancer.
Of 44 children with Nl, 57% (n=25) had acute lymphoblastic leukemia (ALL), 18% (n=8) had non-Hodgkins lymphoma, 9% (n=4) had acute myeloblasts
leukemia (AML), 7% (n=3) had neuroblastoma, and 9% (n=4) had other solid tumors.