Consecutive phases vary, giving rise to a kinetically distinct mitotic pool in which numbers expand to include the myeloblasts
, progranulocytes and myelocytes - loosely referred to as the fixed components of the microenvironment.
Leukocytosis is invariably present at diagnosis with less than 5% myeloblasts
and varying numbers of promyelocytes, myelocytes, metamyelocytes, basophils, and neutrophils (Slide 1).
A CD34 IHC stain highlighted numerous immature cells consistent with myeloblasts
which were arranged in aggregates and small sheets within the submucosa (Figure 3).
In general, the cells of diffuse large B-cell lymphoma have thick nuclear membranes and basophilic nucleoli, unlike myeloblasts
or monoblasts, which have thin nuclear membranes and pinpoint nucleoli.
9]/l (check every 2 weeks until Basophils <5% CHR, then 3-monthly) No myelocytes, promyelocytes, myeloblasts
in the differential count Platelet count <450x[10.
There was an increased number of immature neutrophils including all stages of neutrophil development except myeloblasts
Cytochrome P450 (CYP) expression in human myeloblasts
and lymphoid cell lines.
9] /1, left shift in the differential blood count with 8% myeloblasts
and 4% erythroblasts.
The tumors are composed of myeloblasts
, which are immature cells of granulocytic origin.
The morphologic features may complicate the diagnostic workup, as the blasts closely resemble myeloblasts
Multidimensional flow cytometry of marrow can differentiate leukemic from normal lymphoblasts and myeloblasts
after chemotherapy and bone marrow transplantation.
MS is a localized mass of myeloblasts
with or without additional immature myeloid cells.