Granulocyte colony stimulating factor increases the number of neutrophils and decreases the frequency of infections by correcting the pause in maturation of myelocytes
6cells/mm2) as well as myelocytes
(mean lymphocytes = 117.
1: Bone marrow aspiration showing myeloid series, myelocytes
and metamyelocytes with features of dysmyelopoiesis.
9]/L, which included 8% blasts, 51% myelocytes
and metamyelocytes, 24% neutrophils, 16% lymphocytes, and 1% basophils.
The incidence of sheathing of veins in myeloid leukemia can be explained by the greater tendency of leukemic infiltration of myelocytes
than lymphocytes (Burgeson and Wegner 1929).
Morphologic Features of t(8;21) and inv(16) Acute Myeloid Leukemia t(8;21) inv(16) * Large myeloid blasts with * Variable number of eosinophils abundant basophilic cytoplasm * Numerous azurophilic granules * All stages of eosinophilic maturation * Perinuclear clearing or hofs * Immature purple-violet cytoplasmic granules * Occasional blasts containing * Mainly evident at the Auer rods promyelocyte and myelocyte
stages Table 2.
Histologic Features * Starry- Tumor Eosinophilic Mitoses/ Sky Case Differentiation Myelocytes
10 HPF Necrosis Pattern 1 P + 8 - - 2 P rare 1 - - 3 B - 9 - - 4 B - 47 - + 5 W + 1 + - 6 W + 1 - - 7 P + 8 - - 8 B - 10 - - 9 P rare 3 - - 10 P + 11 - - 11 W + 1 - - 12 P rare 4 - - 13 P rare 1 - - 14 P rare 3 - - 15 P rare 14 - - 16 P + 14 - - 17 W + 4 - - 18 P rare 1 + - 19 P + 7 + - 20 W + 0 - - 21 P + 2 - - 22 B - 19 + - 23 P rare 7 - - 24 P rare 18 - - 25 P + 7 - - 26 P + 12 + - 27 P + 2 - - 28 B - 3 - - 29 B - 2 - - 30 P + 5 - - * W indicates well differentiated; P, poorly differentiated; B, blastic; HPF, high power field; -, not present; and +, present.
Histologic examination of the spleen indicated a massive intravascular and extravascular accumulation of myeloblasts with a variable proportion of promyelocytes and myelocytes
in the red pulp of the spleen.
The Bone marrow pictures in CML without treatment showing hypercellularity due to excessive proliferation of the granulocytes with myelocytes
predominantly and presence of blast cells from <10% to >20% in the bone marrow and peripheral blood according to the world health organization criteria that divide the CML in to chronic, accelerated phases and blast crisis, there is decreased or normal or increased megekayrioposis as well as moderate to marked reticulin fibrosis with presence of small megakaryocyte containing hypolobulated nuclei, sea-blue histiocytes and gaucher cell and these changes are return to the normal state after treatment and the immunohisto-chemistry is used for differentiating the myeloblastic and lymphoblastic crisis of CML [7,8].
New hematology analyzers now report these automatically in the WBC differential as immature granulocytes, reflecting the presence of metamyelocytes, myelocytes
, and promyelocytes in the sample.
Hematopoietic cells include a diverse set of cell types, including erythroid cells (red blood cells), lymphocytes (white blood cells), and myelocytes
(bone marrow cells).
9]/L with 62% neutrophils, 14% stab cells, 6% metamyelocytes, 4% myelocytes
, and 14% lymphocytes; mean corpuscular volume, 87 fL; and platelet count, 415x[10.