Granulocyte colony stimulating factor increases the number of neutrophils and decreases the frequency of infections by correcting the pause in maturation of myelocytes
6cells/mm2) as well as myelocytes
(mean lymphocytes = 117.
1: Bone marrow aspiration showing myeloid series, myelocytes
and metamyelocytes with features of dysmyelopoiesis.
9]/L, which included 8% blasts, 51% myelocytes
and metamyelocytes, 24% neutrophils, 16% lymphocytes, and 1% basophils.
The incidence of sheathing of veins in myeloid leukemia can be explained by the greater tendency of leukemic infiltration of myelocytes
than lymphocytes (Burgeson and Wegner 1929).
Morphologic Features of t(8;21) and inv(16) Acute Myeloid Leukemia t(8;21) inv(16) * Large myeloid blasts with * Variable number of eosinophils abundant basophilic cytoplasm * Numerous azurophilic granules * All stages of eosinophilic maturation * Perinuclear clearing or hofs * Immature purple-violet cytoplasmic granules * Occasional blasts containing * Mainly evident at the Auer rods promyelocyte and myelocyte
stages Table 2.
9 g/dl, total leukocyte counts/cumm, 121000 [+ or -] 35000 /cumm differential leukocyte count % including mature leucocytes 43% such as neotrophils 21 [+ or -] 7, lymphocyte 8 [+ or -] 2, eosinophils 9 [+ or -] 2, monocytes 5 [+ or -] 3 and immature cells 57% composed of Blast 18 [+ or -] 12, promylocytes 4 [+ or -] 1, Myelocytes
25 [+ or -] 5, Metamyelocytes 9 [+ or -] 2, band cells 13 [+ or -] 3 platelet counts / cumm, 285000 [+ or -] 220000 / cumm respectively were noted in the present study (Table 1).
9]/L with 62% neutrophils, 14% stab cells, 6% metamyelocytes, 4% myelocytes
, and 14% lymphocytes; mean corpuscular volume, 87 fL; and platelet count, 415x[10.
Peripheral smear showed severe anisocytosis, macrocytosis with microcytic RBC population and spherocytes, Nucleated RBCs= 3/ 100 WBCs, neutrophilia with hypersegmented neutrophils, metamyelocytes and myelocytes
Consecutive phases vary, giving rise to a kinetically distinct mitotic pool in which numbers expand to include the myeloblasts, progranulocytes and myelocytes
- loosely referred to as the fixed components of the microenvironment.
17,18 Myeloid precursors show giant myelocytes
and metamyelocytes and hyper - pigmented neutrophils.
9]/l (check every 2 weeks until Basophils <5% CHR, then 3-monthly) No myelocytes
, promyelocytes, myeloblasts in the differential count Platelet count <450x[10.