myeloma

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Related to myeloma protein: plasma cell myeloma, monoclonal protein

myeloma

a usually malignant tumour of the bone marrow or composed of cells normally found in bone marrow

myeloma

[‚mī·ə′lō·mə]
(medicine)
A primary tumor of the bone marrow composed of any of the bone marrow cell types.
References in periodicals archive ?
Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone.
Richard Champlin, Head of the Leukemia and Lymphoma Transplant Section at MD Anderson Hospital (Houston, TX) and a principal investigator on the study, reported 12 of 27 patients evaluated in Phase I had achieved complete remission, defined by the absence of myeloma tumor cells in the bone marrow and the absence of the characteristic myeloma protein in the blood and urine by the most stringent biochemical tests currently in common use.
After treatment with MPT, partial responses defined as myeloma protein reduction of greater than 50% were observed in 93% of patients.
The criteria incorporate a full clinical analysis of disease response, specifically, a "complete response" required 100 percent disappearance of the original myeloma protein from the blood and urine on at least two determinations at least six weeks apart by immunofixation; less than five percent plasma cells in the bone marrow; no increase in size or number of lytic bone lesions; and disappearance of soft tissue tumors (plasmacytomas).
In patients who had previously received one line of chemotherapy, 56 percent of patients in the thalidomide plus dexamethasone arm achieved a greater than 50 percent reduction in myeloma protein levels compared to 46 percent of patients in the conventional chemotherapy arm.