myofilament


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Related to myofilament: myofibril, thin filaments

myofilament

[¦mī·ō′fil·ə·mənt]
(cell and molecular biology)
The structural unit of muscle proteins in a muscle cell.
References in periodicals archive ?
Breakdown and release of myofilament proteins during ischemia and ischemia/ reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation.
TRV120023 increased the sensitivity of cardiac myofilaments to calcium, suggesting that TRV120023 and molecules like it, such as TRV027, can increase cardiac contractile force ("inotropy") through a mechanism distinct from classic inotropes, which are associated with cardiac arrhythmia and increased mortality.
High intensity, unaccustomed, or eccentric exercise can induce muscle damage, characterized by the disruption of myofilaments and cytoskeletal elements (1), (2) as well as an inflammatory response.
A closer look within the cell reveals a series of thin contractile fibers called myofilaments that are the machinery driving these contractions.
At the myofilament level, calcium sensitisation is a stereo-specific action, not dependant on oxygen utilisation, and this enhances the binding of calcium to increase contraction force.
Levosimendan (0R-1259), a myofilament calcium sensitizer, enhances myocardial contractility but does not alter isovolumic relaxation in conscious and anesthetized dogs.
5,25,26) Other features are dilated, rough endoplasmic reticulum; intermediate filaments; and peripheral myofilament bundles, especially in the spindle cells at the periphery of the nodules, indicating fibrohistiocytic, fibroblastic, or myofibroblastic differentiation.
Such drugs may increase contractility by affecting sarcolemmal ion pumps, sarcoplasmic reticular function (flosequinan) or myofilament sensitivity to calcium (levosimendan).
2008) recently reported that isometric contractions induced greater PAP in subsequent shortening compared to lengthening contractions, possibly due to changes in myofilament arrangement, [Ca.
HCM can be subdivided on the basis of genetic findings into myofilament ("sarcomeric") HCM, Z-disc HCM, calcium-handling HCM, and metabolic HCM, depending on which component of the molecular motor of the heart is affected.
2002) reported that physical factors of importance to water-holding are mainly thought to be temperature post mortem, shrinkage of the myofilament lattice post mortem due to pH fall and actomyosin cross bridges, myosin denaturation, structural changes at the fibre and fibre bundle level that lead to an increase of the extra-cellular space.