Myopathy

(redirected from myopathies)
Also found in: Dictionary, Thesaurus, Medical.
Related to myopathies: polymyositis, metabolic myopathies, Mitochondrial myopathies

myopathy

[mī′äp·ə·thē]
(medicine)
Any disease of the muscles. Also known as myopathia.

Myopathy

 

progressive muscular dystrophy; a hereditary disease.

Myopathies can be transmitted as autosomal recessive or dominant, or sex chromosome-linked traits. Myopathies result from metabolic disturbances in muscle cells and a change in the biosynthesis of nucleic acids; the degradation of muscle proteins is considerably more rapid than their biosynthesis. In myopathies, muscles become flaccid and some of the fibers are replaced by fatty tissue. Electron microscopy reveals structural changes in the membranes of muscle cells. The main symptoms of the disease are increasing muscular weakness, symmetrical muscular atrophy, decrease in tendon reflexes and, in the later stages, bone and joint deformity. Autonomic trophic nerve functions are invariably impaired.

Myopathy is treated with anticholinesterase preparations, anabolic hormones, and vitamins B and E. Preventive measures include early diagnosis and detection of the heterozygous carrier state for the myopathy gene by using electrophysiological and biochemical tests.

REFERENCES

Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)

L. O. BADALIAN

References in periodicals archive ?
Rheumatologists are from Venus: Differences in approach to classifying the idiopathic inflammatory myopathies.
The Company's lead candidate, Resolaris(TM), is a first-in-class intravenous protein therapeutic for the treatment of rare myopathies with an immune component (RMIC).
The most common drug-induced myopathies seen by rheumatologists are probably caused by corticosteroids.
Before training, subjects with myopathies had a greater mitochondrial content, along with higher expression of the biogenesis regulator peroxisome proliferator-activated receptor-gamma coactivator-lalpha (PGC-1 alpha).
Myopathies Due to Endocrine Abnormalities Disorders of the thyroid can affect muscle function, sometimes causing weakness and wasting, while in other instances causing stiffness and painful cramps.
It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies.
Inflammatory myopathies is an umbrella term for a group of muscle diseases exemplified by dermatomyositis and polymyositis.
Overall, the time course of recovery and the finding of faster recovery of corrugator supercilii muscles in response to a standard dosage of mivacurium in our patient are within the range of published data from patients without myopathies (3).
3,4,6) Pooled analyses of clinical trials involving pravastatin (7) and atorvastatin concluded that serious myopathies were rare in clinical trials and that study subjects experienced myopathy at no greater rate than placebo subjects.
If you can get patients with myopathies to tell you everything they've been eating, drinking, or snorting, you'll identify the cause of the problem in many cases, Dr.
Features that distinguish IBM from other myopathies, namely polymyositis and dermatomyositis, are its unique clinical and histopathologic presentation and its characteristic lack of responsiveness to immunosuppressive therapy.