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Any disease of the muscles. Also known as myopathia.



progressive muscular dystrophy; a hereditary disease.

Myopathies can be transmitted as autosomal recessive or dominant, or sex chromosome-linked traits. Myopathies result from metabolic disturbances in muscle cells and a change in the biosynthesis of nucleic acids; the degradation of muscle proteins is considerably more rapid than their biosynthesis. In myopathies, muscles become flaccid and some of the fibers are replaced by fatty tissue. Electron microscopy reveals structural changes in the membranes of muscle cells. The main symptoms of the disease are increasing muscular weakness, symmetrical muscular atrophy, decrease in tendon reflexes and, in the later stages, bone and joint deformity. Autonomic trophic nerve functions are invariably impaired.

Myopathy is treated with anticholinesterase preparations, anabolic hormones, and vitamins B and E. Preventive measures include early diagnosis and detection of the heterozygous carrier state for the myopathy gene by using electrophysiological and biochemical tests.


Badalian, L. O., V. A. Tabolin, and Iu. V. Vel’tishchev. Nasledstvennye bolezni u detei. Moscow, 1971.
Hausmanowa-Petrusewicz, I. Myshechnye zabolevaniia. Warsaw, 1971. (Translated from Polish.)


References in periodicals archive ?
Most children with Myotubular Myopathy do not live to see their second birthday and only one per cent survive beyond the age of 10.
Liam has myotubular myopathy - a condition that affects muscle tone and means he needs round-the-clock care.
Glowpoint, TalkPoint and AVI-SPL to provide video conferencing and interactive webcast of first-ever conference on medical advancements in Myotubular Myopathy and Centronuclear Myopathy
Liam Barker, 12, of Linthorpe, Middlesbrough, suffers from severe myotubular myopathy which means he requires round the clock care.