myxedema


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Related to myxedema: Myxedema coma

myxedema

(mĭksədē`mə), condition associated with severe hypothyroidism and lack of thyroid hormone in the adult. In the child it is known as cretinismcretinism
, condition produced in infants and children due to lack of thyroid hormone. It usually results from a congenital defect (e.g., absence of the thyroid, presence of only a rudimentary gland, inability of the gland to produce thyroxine).
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. Symptoms include a dry swelling of the skin, slowed speech and mental awareness, deepened voice, intolerance to cold, fatigue and weakness, and nonspecific degeneration of the heart. Most cases result from atrophy of the thyroid from unknown causes, although surgical removal or irradiation of the gland also precipitates the disorder. Myxedema is treated by administering synthetic preparations of thyroxine (thryoid hormone), liothyronine (triiiodothyronine), a combination of the two synthetic hormones, and desicated animal thyroid.

Myxedema

 

a disease caused by thyroid insufficiency (hypothyroidism) or complete thyroid failure. Thyroid and hypothalamic-pituitary myxedema are differentiated.

Thyroid myxedema may be congenital—resulting from abnormal intrauterine development, toxicoses of pregnancy, or intrauterine infection (syphilis, viral infections)—or acquired—resulting from injury or acute or chronic inflammation of the thyroid gland. This form of myxedema may also result from an autoimmune reaction against the body’s own thyroglobulin. Hypothalamic-pituitary myxedema is due to functional and organic changes that interfere with the production of the TSH-releasing factor of the hypothalamus or the thyrotropic hormone of the pituitary.

The main symptoms of myxedema are mucous edema of the skin and subcutaneous tissue, dry skin, sluggishness, drowsiness, poor memory, physical and mental lassitude, lowered basal metabolism, constant sensitivity to cold, lowered blood pressure, slow pulse, and intestinal sluggishness causing constipation. Myxedematous children suffer from dwarfism, slow bone growth, late eruption of the teeth, brittleness of nails, and mental disorders. Treatment includes the regular administration of thyroid preparations (thyroidin) and triiodothyronine.

REFERENCES

Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv. [Leningrad] 1955.
Tareev, E. M. Vnutrennie bolezni, 3rd ed. Moscow, 1957.
Mnogotomnoe rukovodstvo po patologicheskoi fiziologii, vol. 4. Moscow [1966]. Pages 228–29.

L. M. GOL’BER

myxedema

[‚miks·ə′dē·mə]
(medicine)
A condition caused by hypothyroidism characterized by a subnormal basal metabolic rate, dry coarse hair, loss of hair, mental dullness, anemia, and slowed reflexes.

myxoedema

(US), myxedema
a disease resulting from underactivity of the thyroid gland characterized by puffy eyes, face, and hands and mental sluggishness
References in periodicals archive ?
Key to diagnosis is understanding that myxedema coma is diagnosed clinically based on presentation and is supported by other laboratory values.
Levothyroxine Sodium for Injection is an L-thyroxine product indicated for the treatment of myxedema coma, which produces a gradual increase in the circulating concentrations of levothyroxine (T4) in hypothyroid patients.
They cover signs and symptoms; the genetic, immune system, and environmental aspects of pathology in hyperthyroid disorders; coexisting conditions like nodular disease and vitamin B12 deficiency; conventional treatments; alternative and complementary therapies; hyperthyroidism in pregnancy, the postpartum period, and children and adolescents; and Graves' ophthalmopathy and other extrathyroidal manifestations, such as euthyroid Graves' disease, pretibial myxedema, and thyroid acropachy.
One of the earliest documents correlating this was an 1888 compilation of case reports of those suffering from myxedema, a late consequence of severe hypothyroidism.
Use NUCYNTA ER with caution in patients with conditions accompanied by hypoxia, hypercapnia, or decreased respiratory reserve, such as: asthma, chronic obstructive pulmonary disease or cor pulmonale, severe obesity, sleep apnea syndrome, myxedema, kyphoscoliosis, central nervous system (CNS) depression, or coma.
8) Clinically, the differential diagnosis includes xanthomatosis, colloid milium, myxedema, and amyloidosis.
No pretibial myxedema was noted in this group of patients and there was no difference in the familial history of autoimmune disease between these groups.
In addition to Munchausen's syndrome, he coined the name myxedema madness (8).
Autoimmune diseases of the thyroid gland are the most common autoimmune diseases in humans, and encompass a wide spectrum of clinical presentations, ranging from Graves' disease (GD), Graves' ophthalmopathy (GO), Hashimoto's thyroiditis, and idiopathic myxedema.
Anti-bovine TSH antibodies in patients with Graves' disease and primary myxedema.
Use with caution and in reduced doses in older or debilitated patients, as well as patients with renal or hepatic insufficiency, Addison's disease, delirium tremens, myxedema or hypothyroidism, prosthetic hypertrophy or urethral stricture, toxic psychosis.