nalidixic acid


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nalidixic acid

[¦nal·ə¦dik·sik ′as·əd]
(pharmacology)
C12H12N2O3 Pale buff, crystalline powder; melting point is 229-230°C; soluble in chloroform and in potassium hydroxide and sodium hydroxide solutions; used as an antibacterial drug in humans and animals.
References in periodicals archive ?
Another set of five tubes supplemented with nalidixic acid at a dosage of 20 [micro]g/mL was inoculated with 0.
Sulfamethoxazole/trimethoprim resistance was observed initially, followed by resistance to nalidixic acid, erythromycin, and chloramphenicol during the early 2000s.
Xylose lysine agar plates supplemented with Tergitol 4 (XLT4; Difco, Becton Dickson, Sparks, MD, USA) were poured after supplementing 20 mg/L nalidixic acid and 25 mg/L novobiocin (Sigma, St.
Discs used were: ciprofloxacin 5 [micro]g; nalidixic acid 30 [micro]g; tetracycline 30 [micro]g; and erythromycin 15 [micro]g (Becton Dickinson & Co.
They were serially plated on tryptic soy agar containing 50 micrograms per mL of nalidixic acid.
The following disks were used (concentration in [micro]g except where indicated), furazolidone (FX, 100), ampicillin (AM, 10), azithromycin (AZM, 15), amikacin (AN, 30), ciprofloxacin (CIP, 5), co-trimoxazole (Co, 25), chloramphenicol (C, 30), doxycyclin (D, 30), erythromycin (E, 15), gentamicin (GM, 10), kanamycin (K, 30), neomycin (N, 30), nalidixic acid (NA, 30), norfloxacin (NOR, 10), ofloxacin (OFX, 5), streptomycin (S, 10), tetracycline (TE, 30), cefotaxime (CTX, 30) and ceftriaxone (CRO, 30).
coli Enterococcus faecalis Agent Zone Diameter (mm) Zone Diameter (mm) Trial 1 Trial 2 Trial 3 Trial 1 Trial 2 Streptomycin 16 18 16 0 0 Tetracyclin 22 24 22 24 24 Erythromycin 8 0 8 26 26 Oxacillin 0 0 0 8 8 Chloramphenicol 26 26 24 20 22 Penicillin 0 0 0 24 24 Ampicillin 8 8 8 28 28 Nalidixic acid 24 24 24 0 0 Gentamicin 22 22 22 12 12 Cephalothin 20 20 18 14 14 Nitrofurantoin 18 18 18 18 18 Triple sulfa 30 30 30 8 8 Vancomycin 0 0 0 20 22 Carbenicillin 8 8 8 26 26 Antimicrobial Antibiotic Resistance Agent (S/I/R) (a) E.
The researchers determined the existence of viable counts of bacteria on Tryptic soy agar supplemented with rifampicin and nalidixic acid.
All isolates were susceptible to ampicillin, augmentin, trimethoprim, sulfamethoxazole, chloramphenicol, streptomycin, tetracycline, kanamycin, imipenem, nalidixic acid, ciprofloxacin, ceftriaxone and ceftazidime.
Agents * that may cause haemolytic anaemia in G6PD deficiency * Antimalarials: primaquine, chloroquine, sulfadoxine-pyrimethamine * Sulphonamides and sulphones: co-trimoxazole, dapsone, salazopyrin * Other antibacterials: nalidixic acid, nitrofurantoin, chloramphenicol * Analgesics: aspirin (high doses) * Miscellaneous: vitamin K analogues, naphthalene (mothballs and henna), probenecid, methylene blue * Fava beans * Disclaimer--the lists provided are examples of commonly used drugs and are not inclusive of all drugs reported to cause haemolytic anaemia.
Most of the isolates were resistant to tetracycline and nalidixic acid.