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narcolepsy
(redirected from narcoleptics)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson 0.57 sec.
narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and recurring unwanted episodes of sleep ("sleep attacks"). People with narcolepsy may abruptly fall asleep at almost any time, including while talking, eating, or even walking. The attacks may range from embarrassing or inconvenient to severely disabling, interfering with a person's daily life. An estimated 125,000–250,000 people in the United States have narcolepsy; it occurs about equally in males and females.

Most people with narcolepsy also experience cataplexy, sudden muscular weakness without loss of consciousness, which usually accompanies laughter or anger. Other symptoms, occurring just after falling asleep or upon awakening, include sleep paralysis (a feeling that one cannot move) and vivid hallucinations.

The cause of narcolepsy is not known with certainty, and there is no cure. Treatment, including regular planned naps and the use of stimulant drugs (e.g., amphetamines amphetamine (ămfĕt`əmēn), any one of a group of drugs that are powerful central nervous system stimulants .
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) plus antidepressants antidepressant, any of a wide range of drugs used to treat psychic depression . They are given to elevate mood, counter suicidal thoughts, and increase the effectiveness of psychotherapy .
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 for cataplexy, can help to control its symptoms.


narcolepsy

Sleep disorder with sudden, uncontrollable spells of daytime sleep and disturbances of nighttime sleep. It usually begins in youth or early adulthood and is presumably due to dysfunction of certain brain structures. Narcoleptics can fall asleep anywhere and anytime—for instance, while talking, eating, or driving. Sleep usually lasts a moment, rarely over an hour, and the narcoleptic is easily awakened. Sleep paralysis, normal when falling asleep or waking, occurs during full consciousness in narcolepsy, with brief but complete inability to move.



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This is really good news for human narcoleptics because now the pathway for therapy is clear," says Thomas Kilduff of SRI International in Menlo Park, Calif.
Catalepsy - a temporary decrease or loss of muscle control - can cause narcoleptics to fall.
Xyrem has demonstrated an acceptable safety profile in narcoleptics with cataplexy when administered in nightly divided doses of 6 to 9 g with a recommended starting dose of 4.
 
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