(redirected from necrobiosis lipoidica)
Also found in: Dictionary, Thesaurus, Medical, Wikipedia.


Death of a cell or group of cells under either normal or pathologic conditions.



the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

References in periodicals archive ?
For ulcerative lesions of PG, frequent differential diagnosis include infective such as necrotizing fascitis, vascular occlusive or venous disease, necrobiosis lipoidica, livedoid vasculitis, sarcoidosis, or cutaneous malignancies such as squamous cell carcinoma and basal cell carcinoma, vasculitic processes such as Wegener's, malignancy such as lymphoma or leukemia, and pustular drug reactions.
Localized granuloma annulare must be differentiated from the most common annular lesion, tinea corporis, as well as other annular lesions, including necrobiosis lipoidica and erythema migrans.
Most frequently observed skin disease was bacterial infections (26%), followed by fungal infections (22%), acanthosis nigricans (20%), diabetic foot (16%), nail changes (16%), acrochordons (10%), diabetic dermopathy (9%), necrobiosis lipoidica (9%), viral infections (8%) pruritus (8%) and xanthelasma (8%).
Topical tacrolimus in granuloma annulare and necrobiosis lipoidica.
A spectrum including pretibial pigmented patches and necrobiosis lipoidica diabeticorum.