necrotizing fasciitis

Also found in: Dictionary, Medical, Acronyms, Wikipedia.
Related to necrotizing fasciitis: necrotizing enterocolitis

necrotizing fasciitis,

a quickly progressing infection of the skin that spreads along the fascia, the tissue that covers the muscles. (Necrotizing infections that spread along the outer skin layers are known as necrotizing cellulitis.) Necrotizing fasciitis is most commonly caused by toxins released by a strain of Group A streptococcal bacteria (S. pyrogenes; see streptococcusstreptococcus
, any of a group of gram-positive bacteria, genus Streptococcus, some of which cause disease. Streptococci are spherical and divide by fission, but they remain attached and so grow in beadlike chains.
..... Click the link for more information.
), but it also may be caused by Staphylococcus aureus (see staphylococcusstaphylococcus
, any of the pathogenic bacteria, parasitic to humans, that belong to the genus Staphylococcus. The spherical bacterial cells (cocci) typically occur in irregular clusters [Gr. staphyle=bunch of grapes].
..... Click the link for more information.
); other bacteria may also be present.

Popularly known as "flesh-eating disease," the infection typically begins as a warm, very painful red swelling, sometimes at the site of a minor injury. Patients usually have a high fever and may feel ill, dizzy, and confused; the infection spreads rapidly, and tissue in older infected areas turns purplish or black as it dies. Necrotizing fasciitis is treated with surgery (to remove infected tissue) and intravenous antibiotics (high-dose penicillin and clindamycin). If not treated promptly, the toxins produced by the bacteria can cause septic shock and lead to death within 24 hours; roughly 30% of infected patients die.

Mentioned in ?
References in periodicals archive ?
Table 1: The laboratory risk indicator for necrotizing fasciitis (LRINEC) score
Factors affecting the mortality of Necrotizing Fasciitis involving the upper extremities.
The most important laboratory scoring system for early diagnosis is the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score.
The only remedy for necrotizing fasciitis is intravenous antibiotics and a surgical procedure called debriding to remove dead and dying tissue.
One dose of IVIG was given since he was due for his routine dose for his rheumatological disorders, and given that IVIG may improve outcomes of necrotizing fasciitis from GAS infection [8].
A case of mortal necrotizing fasciitis of the trunk resulting from a centipede (Scolopendra moritans) bite.
Known in the medical community as necrotizing fasciitis or NF, the flesh-eating bacteria is often caused by the same bacterium that causes strep throat.
The National Necrotizing Fasciitis Foundation (NNFF) is a non-profit organization established in 1997 by two survivors of the disease, which is dedicated to becoming the world's leading resource for information regarding necrotizing fasciitis, as well as repository of cases reported worldwide.
Modern concepts of the diagnosis and treatment of necrotizing fasciitis.
Microbial agents in necrotizing fasciitis are included streptococci, enterobacterecea, and anaerobic bacteria.
Necrotizing fasciitis is a rapidly progressive infectious disease that primarily involves the fascia and subcutaneous tissue.

Full browser ?