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negative staining

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.03 sec.
negative staining [′neg·əd·iv ′stān·iŋ]
(biology)
A method in microscopy for demonstrating the form of cells, bacteria, and other small objects by staining the ground rather than the objects.


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[FIGURE 3 OMITTED] Figure 4 is the digital histogram interpretation of P2 population (see Figure 2) showing negative staining of all events.
I found and read an original article, titled "Histologic Variants of Infiltrating Urothelial Carcinoma" by Zhai et al,1 which had the sentence "Although urothelial carcinoma with glandular differentiation will show positive staining for CK7 and negative staining for villin, CDX2, and CK20, metastatic adenocarcinoma of the colon is CK7 negative and shows positive staining for villin, CDX2, and CK20,10" on page 1245.
Immunohistochemically, the specimen showed negative staining for HMB-45 and melan-A and positive staining for S- 100 protein, favoring a diagnosis of malignant melanoma.
 
 
 
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