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nephropathy |
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Our data justify inclusion of hantavirus infection in the differential diagnosis of patients from Africa with unexplained febrile nephropathies or noncardiogenic pulmonary edema. In our study performed on 1,800 Sprague-Dawley rats, which are less susceptible to the spontaneous development of nephropathies than Fischer rats, we observed a dose-related, statistically significant increase in the incidence of dysplastic hyperplasia and carcinoma of the renal pelvis in females, but none in males, compared with the controls. Asian and European forms of hantavirus disease consist of a group of febrile nephropathies known as hemorrhagic fever with renal syndrome (8), clinical features of which differ from the forms described in the Americas. |
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