neurofibrillary tangle


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neurofibrillary tangle

[‚nu̇·rō‚fīb·rə‚ler·ē ′taŋ·gəl]
(pathology)
The accumulation of twisted protein filaments (neurofibrils) within neurons of the cerebral cortex; a characteristic pathological feature found in the brains of Alzheimer's disease patients.
References in periodicals archive ?
They looked for presence of TDP-43 and tau neurofibrillary tangle burden in the hippocampus and the lateral temporal cortex, an area affected in Alzheimer's disease.
PKC Isozymes Regulate Amyloid Plaque and Neurofibrillary Tangle Metabolism
Although they cannot be detected prior to autopsy, characteristic pathologic features of this disease include neurofibrillary tangle and plaque formation and changes in oxidative and inflammatory processes as well as cholinergic neurotransmission.
Others favor different suspects, such as the protein that lies at the base of the neurofibrillary tangle or calcium ions, which figure importantly in many aspects of cell function.
Postmortem studies of human brains and neuroimaging studies have suggested that the disease, especially the neurofibrillary tangle pathology, begins in the entorhinal cortex, which plays a key role in memory.
This includes [18F]-MK-6240, a tau ligand currently being evaluated as a potential Positron Emission Tomography imaging agent for quantifying the brain burden of neurofibrillary tangle pathology in people with AD.
Merck and Cerveau are currently conducting an open-label Phase 1 study to investigate the safety and characterize the use of [18F]MK-6240 as a PET imaging agent for quantifying brain burden of neurofibrillary tangle pathology.
The truncated tau (delta tau, aka TauC3 fragment) has higher rates and extents of polymerisation in-vitro versus wild-type full-length tau, indicating a role for tau truncation in neurofibrillary tangle formation.
Bohr of the Laboratory of Molecular Gerontology of the National Institute on Aging (NIA), Yujun Hou, and an international team of researchers developed a new model of mice featuring hallmarks of human Alzheimer's including neurofibrillary tangles, failing synapses, neuronal death and cognitive impairment.
Bohr of the, senior investigator and chief of the Laboratory of Molecular Gerontology of the NIA, Yujun Hou, and an international team of researchers developed a new model of mice featuring hallmarks of human Alzheimer's including neurofibrillary tangles, failing synapses, neuronal death and cognitive impairment.
Bohr of the , senior investigator and chief of the Laboratory of Molecular Gerontology of the NIA, Yujun Hou, and an international team of researchers developed a new model of mice featuring hallmarks of human Alzheimer's including neurofibrillary tangles, failing synapses, neuronal death and cognitive impairment.
These research projects are for studies of an early stage imaging agent (MK-6240) to be used in positron emission tomography (PET) scans for assessing the status and progression of neurofibrillary tangles (NFTs) in the brain.