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neurofilament |
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neurofilament [‚nu̇·rō′fil·ə·mənt] (physiology) A type of intermediate filament, composed of three polypeptides (NF-L, NF-M, and NF-H), that helps support and strengthen the axons of nerve cells. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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63) The rate of distal neurofilament protein transport also is delayed in distal axons with aging. Clinical and demographic findings can help make distinctions, as can pertinent immunohistochemical reactions to synaptophysin, chromogranin, neuron-specific enolase (NSE), neurofilament protein (NFP), S-100 protein, keratin, CD45RB, desmin, CD99, and HMB45. Associated with this neuronal loss is the presence of large eosinophilic inclusions, called Lewy bodies, within the remaining pigmented neurons, made up of a series of proteins, including neurofilaments, [alpha]-synuclein fibrils, ubiquitin, parkin, and proteasomal elements. |
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