neutralizing antibody


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neutralizing antibody

[′nü·trə‚līz·iŋ ′ant·i‚bäd·ē]
(immunology)
An antibody that reduces or abolishes some biological activity of a soluble antigen or of a living microorganism.
References in periodicals archive ?
24) In the present study, we report the induction of neutralizing antibody response by vaccine candidate and its efficacy in BALB/c mice.
In a second study, a booster dose administered to 40 subjects who had received primary immunization but no longer had protective neutralizing antibody titers resulted in protective titers in all subjects when the booster was administered at 11 months (n = 16) or 23 months (n = 24) after the first dose (7).
The HA and NA are included to induce neutralizing antibody responses, whereas the M1 may induce cell-mediated immune responses that provide protection against drifted (i.
The inability of a mixture of 4 dengue chimeric viruses to elicit an initial primary neutralizing antibody response in nonhuman primates and susceptible humans was recognized during preclinical testing and explained by the phenomenon of interference (2).
For example, to elicit broadly neutralizing antibodies called VRC01-class antibodies that neutralize 90 percent of known HIV strains, you could try using the HIV envelope protein as your immunogen," Schief said, and added, "But you run into the problem that the envelope protein doesn't bind with any detectable affinity to the B cells needed to launch a broadly neutralizing antibody response.
In a recently published paper, the team reported on the isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection.
Laboratory methods for measuring EV71 serum neutralizing antibody titers followed standard protocols (7) and used a local strain (TW/E59/2002 [B4 genotype]) and rhabdomyosarcoma cells.
Having blood samples from such an early stage enabled researchers to pinpoint the particular "founder" virus that triggered the immune system to make an immature broadly neutralizing antibody against HIV, as well as the cell from which that antibody emerged.
Studies have shown that heterologous neutralizing antibody titers are inversely correlated with severity of a second infection.