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Neutrophil

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neutrophil [′nü·trə‚fil]
(histology)
A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.

Neutrophil 

(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)



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Some specific topics covered include neutrophil apoptosis and innate immunity, glial regulation of beta-amyloid deposition and neurodegeneration in Alzheimer's disease, and the role of avian acute phase protein ovotransferrin in modulating phagocyte function.
While the severity of inflammation did not show an overall reduction, there was a marked reduction in neutrophil (white blood cell) infiltration after both xeno-and-allo-transplantation.
Unaccustomed and strenuous exercise can also cause neutrophil activation and muscle damage that involves protein degradation and ultra structural changes (Komulainen et al.
 
 
 
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