Neutrophil


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Related to Neutrophil: hypersegmented neutrophil

neutrophil

[′nü·trə‚fil]
(histology)
A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.

Neutrophil

 

(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

References in periodicals archive ?
NLR is easily calculated from routine blood test by dividing the absolute neutrophil ratio to absolute lymphocyte ratio.
In addition to causing maturation defects, alcohol consumption also leads to a number of other changes related to neutrophils such as neutropenia, neutrophil delivery or the ability of the cell to reach sites of inflammation as well as decreased ability to adhere to endothelium as a result of either reduced production of leukotrienes or the inability to respond to leukotrienes.
The absolute neutrophil counts were calculated from WBC counts and the percentage of neutrophils obtained from the differential counts.
The individuality of nuclear chromatin with particular reference to polymorphonuclear neutrophil leukocytes.
Continuous variables are presented as the mean and standard deviation, and the receiver operating characteristics (ROC) test was used to determine the accuracy of leucocyte, neutrophil, eosinophil, and platelet counts, neutrophil percentage, and MVP for predicting perforation of appendicitis.
To confirm that abah acts to block the recruitment rather than the ontogeny of neutrophils, whole body neutrophil counts were performed in the presence of the abah and the vehicle-only control.
Thus, in instances where there is an excess of inflammatory stimuli, the prolongation of the neutrophil lifespan can contribute greatly to the morbidity (and possible mortality) associated with inflammation [13,21,22].
This study provides a good insight into the possible mechanisms behind the anti-inflammatory effect of the flavonoid vitexin, and, of note, is the first study to demonstrate its multi-target activity through inhibition of leukocyte migration, particularly the neutrophils, and through inactivation of three pro-inflammatory pathways which may lead to inhibition of inflammatory cytokines, NO and PGE2release.
In this study, Kwon et al found that lymphocyte count was associated with Gleason score upgrading and neutrophil count was associated with biochemical failure; NLR was not found to have association with any of the study endpoints.
Data were retrospectively collected on white blood cell count, neutrophil count, neutrophil percentage, lymphocyte count, lymphocyte percentage, neutrophil to lymphocyte ratio, platelet count, mean platelet volume, platelet distribution width and plateletcrit from the complete blood count test performed on patients upon their admission to the emergency department of the hospital.