Direct evidence of CB2-mediated anti-nociceptive
effects was first reported in 1999 using the selective CB2 agonist, HU-308, which markedly decreased nociceptive
behavior in the hind paw model of formalin treated rats (27).
Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive
facilitation in rats.
3] receptors, the glutamate at NMDA receptors is involved in the nociceptive
responses in inflamed regions.
TABLE 1 (4) lists the possible mechanisms of pain, which can be broken down into 4 categories: peripheral nociceptive
(inflammatory or mechanical), peripheral neuropathic (underlying damage to a peripheral nerve), central (referring to when the central nervous system is the primary entity involved in maintaining the pain), or any combination of the 3.
blink reflex and pain related evoked potentials in hypnic headache.
Neuropathic pain was reported as more intense than nociceptive
The resulting RF lesion may be limited and heating the center of the nucleus might not destroy enough nociceptive
fibers in the annulus.
activity of acetic acid is associated with the release of inflammatory mediators, such as prostaglandins, sympathomimetic amines and several cytokines (IL-1[beta], TNF-[alpha], IL-8) released from resident peritoneal macrophages and mast cells (Ribeiro et al.
Local corticosteroid application blocks transmission in normal nociceptive
Comparison of active constituents, acute toxicity, anti- nociceptive
and anti-inflammatory activities of PoranasinensisHemsl.
NCS consists of four subscales--motor response, verbal response, visual response, and facial expression--and was developed from pain scales for noncommunicative patients with advanced dementia or for newborns to assess behaviors linked to nociceptive
pain in the VS/UWS and MCS.
Pain measurement is achieved through nociceptive
stimulus in animal experiments and may be thermal, mechanical, or chemical in nature.