nonsense suppression


Also found in: Medical.

nonsense suppression

[′nän‚sens sə‚presh·ən]
(genetics)
Suppression of the termination effect of a nonsense codon on a growing polypeptide chain, allowing return to the normal phenotype.
References in periodicals archive ?
Therapeutic nonsense suppression is a potentially powerful approach for the treatment of the large number of genetic disorders caused by nonsense mutations.
The finding of improvement over placebo at the low dose of ataluren but not at the high dose is consistent with subsequent analysis of non-clinical data which suggest a bell-shaped dose response curve as a class-based effect for drugs that promote nonsense suppression.
Investigators are also investigating nonsense suppression, a strategy that attempts to stabilize the ribosome to "read through'" the nonsense mutation that causes premature termination of the translation of the dystrophin gene in up to 15% of patients with DMD, as well as a subset of other MD patients.