nonsteroidal anti-inflammatory drug


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nonsteroidal anti-inflammatory drug,

a drug that suppresses inflammation in a manner similar to steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
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, but without the side effects of steroids; commonly referred to by the acronym NSAID (ĕn`sĕd). Also effective in alleviating pain and fever, NSAIDs are commonly used to treat the symptoms of arthritis, gout, bursitis, painful menstruation, and headache. They act by inhibiting the synthesis of prostaglandins, leukotrienes, and other compounds that are involved in the inflammatory process.

Aspirin is technically an NSAID, but the term is often used to refer to nonaspirin products. The first nonaspirin NSAIDs were introduced in 1964. Common NSAID products include diclofenac (Cataflam, Voltaren), indomethacin (Indocin), ketorolac (Acular, Toradol), and piroxicam (Feldene). Ibuprofenibuprofen
, nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxen and ketoprofen, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967.
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, naproxennaproxen
and naproxen sodium,
potent nonsteroidal anti-inflammatory drugs (NSAID) used to alleviate the minor pain of arthritis, menstruation, headaches, and the like, and to reduce fever.
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, and ketoprofenketoprofen
, nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and fever-reducing effects, used to relieve the symptoms of headaches, arthritis, and painful menstruation.
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 are available as over-the-counter drugs in the United States. The cox-2 inhibitors, such as celecoxib (Celebrex), selectively inhibit clooxygenase-2 (cox-2), an enzyme that causes pain and inflammation in arthritic joints, but do not interfere with cox-1, which protects the stomach and intestinal lining from ulceration. Very common drugs, NSAIDs are taken daily by an estimated 3 million Americans.

Although they are often considered easier to tolerate than aspirin, and most do not have as strong an anticlotting effect as aspirin, NSAIDS can have serious side effects, particularly gastrointestinal ulcers and upper gastrointestinal tract bleeding and perforation in those who take the drugs on a regular basis. NSAID-related gastropathy results in more than 2,000 deaths in the United States each year.

References in periodicals archive ?
Up to 30 percent of patients taking traditional nonsteroidal anti-inflammatory drugs develop persistent gastrointestinal symptoms and more than 1 in 10 patients discontinue treatment with these drugs because of undesirable side effects.
Take a careful history on the use of over-the-counter nonsteroidal anti-inflammatory drugs.
Among poultice preparations containing nonsteroidal anti-inflammatory drugs (NSAIDs), it is the first poultice for usage once per day to be granted approval for manufacture.
Appendices include a comparison of nonsteroidal anti-inflammatory drugs, but the book was published before the latest FDA recommendation on COX-2 inhibitors.
Nonsteroidal anti-inflammatory drugs were discontinued, and physiotherapy and equipment with a corset were initiated.
While nonsteroidal anti-inflammatory drugs (NSAIDs) may offer short-term relief from the pain and inflammation associated with many sports-related injuries, their long-term use appears to be an inadequate treatment for knee osteoarthritis (OA) pain, and is not always safe.
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) are known to block the active site of COX and, therefore, inhibit prostaglandin production.
It is treated with a period of rest and in the acute phase with mild nonsteroidal anti-inflammatory drugs and muscle relaxants.
Nonsteroidal anti-inflammatory drugs are sometimes used, but should not be used in the third trimester.
Several recent studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) provide protection against the development of Alzheimer's disease (AD).
Nonsteroidal anti-inflammatory drugs such as ibuprofen and sulindac or prescription arthritis drugs such as indomethacin have been shown to delay the onset.