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nucleocapsid |
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nucleocapsid [¦nü·klē·ō′kap·səd] (virology) The nucleic acid of a virus and its surrounding capsid. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Even with aMPV subtypes, the whole-virus antigen-based detection systems did not show cross-reaction between subtypes, whereas a conserved region of nucleocapsid protein or synthetic peptide-based detection systems showed cross-reactivity. Some of the targets that might be important include structural elements (such as the highly conserved zinc finger motif of the HIV nucleocapsid or the viral enzymes integrase and RNase H), regulatory and accessory proteins, processes (such as transcription, nuclear import and export of viral nucleic acid, and macromolecular interactions), and host targets (adhesion molecules, transcription factors, apoptosis, and signaling pathways). [26] Immunohistochemical studies have demonstrated the expression of measles virus nucleocapsid [11] and fusion [27] proteins in chondrocytes, osteocytes, osteoblasts, and the connective tissue, especially in otospongiotic (resorptive) areas. |
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