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nucleophile

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nucleophile

Atom or molecule that contains an electron pair available for bonding and in chemical reactions therefore seeks a positive centre, such as the nucleus of an atom or the positive end of a polar molecule (see covalent bond; electric dipole). In the Lewis electron theory (see acid-base theory), advanced by the U.S. chemist Gilbert Lewis (1875–1946) in 1923, nucleophiles are by definition Lewis bases. Examples include the hydroxide ion (OH−), the ions of the halogens chlorine, bromine, and iodine (Cl−, Br−, and I−, respectively), ammonia (NH3), and water (H2O). See also base; electrophile.
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To form an adduct, the chemical must have an electrophilic site to which a nucleophile on the biomolecule (usually sulfur or nitrogen) can covalently bind.
Biologic monitoring of exposure to environmental chemicals throughout ... by Needham, Larry L. / Environmental Health Perspectives
The structural results and experimental characterization of the Y6F mutant suggest that the hydrogen bond between Tyr6 and the enzyme-bound nucleophile helps to lower the p[K.
Macromolecular crystallography and structural biology databases at ... by Gilliland, Gary L. / Journal of Research of the National Institute of Standards and Technology
C-C Crossing Heleroarenes with Nucleophiles in Synthesis of
InnoCentive Sponsors Scientific Conference at St. Petersburg State ... by Business Wire
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