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nucleoside

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nucleoside

Any of a class of organic compounds, including structural subunits of nucleic acids. Each consists of a molecule of a five-carbon sugar (ribose in RNA, deoxyribose in DNA) and a nitrogen-containing base, either a purine or a pyrimidine. The base uracil occurs in RNA, thymine in DNA, and adenine, guanine, and cytosine in both, as part of the nucleosides uridine, deoxythymidine, adenosine or deoxyadenosine, guanosine or deoxyguanosine, and cytidine or deoxycytidine. Nucleosides usually have a phosphate group attached, forming nucleotides. Usually obtained by decomposition of nucleic acids, nucleosides are important in physiological and medical research. Those that are not part of nucleic acids include puromycin and certain other antibiotics produced by fungi.



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Ed4T, which was developed by Yale University, Kagoshima University and Showa University, is a nucleoside reverse transcriptase inhibitor with enhanced anti-HIV-1 activity.
Roche announced in April that it would stop malting its nucleoside reverse transcriptase inhibitor Hivid (ddC) and its protease inhibitor Fortovase in 2006.
One person was just on Kaletra and saquinavir with no nucleosides, and the other was on nucleosides but had high-level resistance to them.
 
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