oligomycin


Also found in: Medical, Wikipedia.

oligomycin

[ə‚lig·ə′mīs·ən]
(microbiology)
Any of a group of antifungal antibiotics produced by an actinomycete resembling Streptomyces diastachromogenes ; the colorless, hexagonal crystals are soluble in many organic solvents.
References in periodicals archive ?
Changes in ATP concentration could be measured in HeLa cells upon treatment with oligomycin or [Ca.
To study the sensitivity of the assay, several classical inhibitors of the mitochondrial energy-generating system were added to control fibroblasts: rotenone (for complex I), antimycin A (complex III), azide (complex IV), oligomycin (complex V), atractyloside [adenine nucleotide transporter (ANT)], [alpha]-hydroxycyanocinnamate (pyruvate carrier), and arsenite (PDHc and [alpha]-ketoglutarate dehydrogenase).
Oligomycin hampers the oxidation of pyruvate and when added to the cell, it switches off the current.
Effects of oligomycin (Oli) on different mitochondrial parameters.
Oligomycin, carbonyl cyanide-p-trifluorome-thoxyphenylhydrazone (FCCP), rotenone, and antimycin A were obtained from Seahorse Bioscience (North Billerica, MA, USA) in XF Cell Mito Stress Test kit (#103015-100).
5] cells/mL) 4h after resuspending the cells in PBS containing L-glutamine (2mM), in the presence of glucose (2g/L) or its absence to stimulate OXPHOS; when necessary, oligomycin (2.
05 Saline Monocrotaline 5 50 Saline Nicotinic acid 200 2,000 Saline Oligomycin 0.
Vignais, "Interactions between the oligomycin sensitivity conferring protein (OSCP) and beef heart mitochondrial F1ATPase.
M3 continued to increase oxygen consumption, after the addition of oligomycin under both normo-and hyperglycaemic conditions to 1.
Indeed, mitochondrial-targeting chemicals, such as antimycin, azide, chloramphenicol, carbonyl cyanide, m-chlorophenylhydrazone carbonyl cyanide, p-(trifluoromethoxy)phenylhydrazone, ethidium bromide, myxothiazol, rotenone, and oligomycin tetracycline [20-30], inhibit the myogenic process.
Subsequent experiments with the F1F0-ATPase inhibitor oligomycin (5 [micro]g/ml) were performed to check whether a possible drop in the RCR derives from uncoupling or increased intramitochondrial metabolism of ATP.
2] flux was performed sequentially as follows: pyruvate (5 mM) and malate (5 mM), ADP (3 mM), cytochrome c (10 [micro]M), succinate (10 mM), oligomycin (1 [micro]g/mL), and KCN (10 mM) [15].