oncogenesis

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Related to oncogenic: oncogenic osteomalacia, Oncogenic viruses

oncogenesis

[¦äŋ·kō′jen·ə·səs]
(medicine)
Processes of tumor formation.
References in periodicals archive ?
APX3330 is a small molecule that targets the DNA repair protein APE1/Ref-1, a dual function protein involved in both DNA repair and redox-signaling co-activation of oncogenic transcription factors.
Bissell said that they found that overexpression of GLUT3 in the non-malignant human breast cells activated known oncogenic signaling pathways and led to the loss of tissue polarity and the onset of cancerous growth.
In contrast to a very small subset of the many immunocompetent women infected with oncogenic types of HPV who develop cervical cancer, women infected with HIV are thought to be 3-5 times more likely to develop cervical lesions that can become cancerous.
Oncogenic HPV infection was significantly associated with having a high number of lifetime female sexual partners, and a high number of male anal-sexual partners.
The overall prevalence of oncogenic HPV subtypes was 30% and that of nononcogenic subtypes was 38%, they said (Lancet 2011 March 1 [doi:10.
In early January, the company signed an exclusive license agreement and research collaboration with the Center for Cell and Gene Therapy (CAGT), Baylor College of Medicine in Houston, for the commercialization of an innovative cell-based treatment for cancers associated with the oncogenic Epstein Bar virus (EBV).
With the recent classification of certain microRNAs as anti-tumorigenic or oncogenic, our work will be centered on developing diagnostic markers from these non-coding genes.
The topics include the NF-[kappa]B family of transcription factors and its regulation, a structural guide to proteins of the NF-[kappa]B signaling module, ubiquitination and degradation of the inhibitors of NF-[kappa]B, selectivity of the NF-[kappa]B response, its oncogenic activation, the nuclear factor NF-[kappa]B pathway in inflammation, roles of the pathway in lymphocyte development and function, its role in the immune response of Drosophila, and using forward genetics to discover novel regulators of it.
Perhaps excess transcription factors (the proteins) for oncogenic genes could be absorbed by other cells after leaking out of a cancer cell.
Such tests do not make it possible to assess the virus' oncogenic activity (ability to cause cancer).
We know that FOXO3a is inactivated in about 80% of breast tumors, and that it's likely to be inactivated in other solid tumors because three major oncogenic pathways separately target it," Hung points out.
With the increased knowledge that certain oncogenic subtypes of human papillomavirus (HPV) cause the development of the disease, a national program of vaccination against two of the 15 oncogenic viruses began in April 2007.