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Organoid

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Organoid 

one of the permanent components of animal and plant cells. Each organoid performs specific functions that are vital for cell survival. Thus, any cell activity is a consequence of the coordinated operation of interconnected components, particularly organoids. Organoids include mitochondria, the Golgi apparatus, the centrosomes, the endoplasmic reticulum, ribosomes, and cytoplasmic microtubules. Organoids in plant cells include plastids and spherosomes. The classification of lysosomes as organoids is controversial. The term “organoid” derives from the similarity of these cell components to the organs of a multicellular organism. Organoids are contrasted to temporary cell inclusions, which appear and disappear in the metabolic process.



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Microscopically, the tumor is composed of solid and trabecular sheets of oncocytes arranged in an organoid pattern (figure).
An organoid or trabecular pattern may lead to confusion with high-grade neuroendocrine carcinoma, but clues to diagnosis include numerous tumor-infiltrating lymphocytes and a pushing tumor border configuration.
The relationship of the WHO classification and previous histologic classifications is as follows: type A corresponds to spindle cell type or medullary type thymoma; AB corresponds to mixed type; B1 corresponds to lymphocyte-rich type, lymphocytic type, predominantly cortical type, or organoid type; B2 corresponds to cortical type; B3 corresponds to epithelial type, squamoid type, or atypical thymoma, or well-differentiated thymic carcinoma; and type C corresponds to thymic carcinoma.
 
 
 
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