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Orotic Acid

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orotic acid [ə′räd·ik ′as·əd]
(biochemistry)
C4H4O4N2A crystalline acid which is a growth factor for certain bacteria and is also a pyrimidine precursor.

Orotic Acid 

(also 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid or uracil-6-carboxylic acid), colorless crystals that are poorly soluble in water and organic solvents; melting point, 323°-345°C (with decomposition). Orotic acid was first extracted from cow’s milk in 1905 and later discovered in the milk of other animals and humans. Concentrated mainly in yeasts and in the liver, it is synthesized from aspartic acid and takes part in the biosynthesis of pyrimidine nucleotides, including uridine-5’-monophosphate and cytidine monophosphates. It also stimulates growth in plants and animals. The potassium salt of orotic acid is used in medicine to treat disorders in protein metabolism.



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While the mechanisms have not been confirmed, it has been hypothesized that orotic acid produced during lactic acid fermentation may inhibit cholesterol production in the liver.
The first ever arginine, citrulline and creatine esters combined with the anabolic salts of orotic acid and a normal acetate ester of clean twenty-beta-hydroxy-ecdysone extort.
 
 
 
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