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A bone-forming cell of mesenchymal origin.



a cell that is involved in bone formation in vertebrate animals and man. Osteoblasts arise during the ossification of skeletal rudiments. In mature bone, they are found only in regions of injury, regeneration, and remodelling. They also take part in the formation and calcification of the intercellular substance of a bone.

References in periodicals archive ?
Osteoblastic osteosarcoma classically presents as an ill-defined sclerotic, radiodense bony lesion in young patients.
Primary osteoblastic cells and rat marrow cells were prepared according to the literature (Liu et al.
Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway.
We also investigated the effects of Ad-TNF-[alpha]-siRNA-BMP-2 on osteoblastic MC3T3-E1 cells to confirm differentiation in conditioned culture media (CM).
PTH and 1,25(OH)2 vitamin D priming to growth factors differentially regulates the osteoblastic markers in MBA-15 clonal subpopulations.
Suppression of osteoblastic phenotypes and modulation of pro- and anti-apoptotic features in normal human osteoblastic cells under a vector-averaged gravity condition.
A key feature is the conspicuous absence of osteoblastic rimming (Figure 4).
Primary rat calvarial osteoblasts (RCO) were cultured for 72 h (3 days) on the micropatterned titanium substrates in order to analyze the effects of the tested surface topographies on osteoblastic differentiation and function.
Eventually, the increased rates of osteoblastic new bone formation during bisphosphonate treatment decline as does osteoclastic bone resorption, and the biochemical markers of bone turnover return to premenopausal ranges.
1999), and bone gla-protein (BGP) is also produced by mature osteoblasts and primarily deposited in the extracellular matrix of skeletal tissue (Wada and Kamiya, 2006), and both ALP and BGP are related to activity of osteoblastic cells.
3) On radiographic imaging the tumor may be osteolytic or osteoblastic, and a sunburst appearance is seen in 30% to 55% of cases.
In the left hip and knee bone scintigraphy, increased osteoblastic activity was considered as heterotopic ossification developing in two separate regions.