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Osteoclast
(redirected from osteoclastic)

    Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
osteoclast [′äs·tē·ə‚klast]
(histology)
A large multinuclear cell associated with bone resorption.
(medicine)
A large surgical apparatus through which leverage can be exerted to effect osteoclasis.
Osteoclast 

a cell that is involved in the destruction and resorption of bone tissue in vertebrate animals and man. An osteoclast contains from three to several dozen nuclei and a great many lysosomes, whose hydrolytic enzymes upon release from the osteoclasts resorb the mineral matrix of bone and calcified cartilage.
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Currently FDA-approved bisphosphonates, including Fosamax (alendronate), Actonel (risedronate), Didronel (etidronate), Boniva (ibandronate), and Reclast (Zometa) (zoledronate), are designed to strengthen bone by inhibiting normal osteoclastic bone resorbing activity, which slows the loss of bone mineral density (BMD), allowing the trabecular architecture to stabilize.
Bisphosphonates: bone strengtheners or bone hardeners? by Lenard, Lane / Townsend Letter
Bone turnover improved selectively in women >70 years old, as assessed by the dualenergy x-ray absorptiometry (DEXA) technique and the decrease of osteoclastic activity.
Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution ... by Life Extension
S12911-2 inhibits osteoclastic bone resorption in vitro.
Comparison of the effects of strontium ranelate and raloxiphene on ... by Yilmaz, Figen; Dogu, Beril; Sahin, Tulay; Sahin, Fusun; Kuran, Banu / From the Osteoporosis World
 
 
 
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