When the researchers deleted p53
completely, the cells became immortal but quickly developed into bone.
However, as previously observed with other genetic variants of p53
, a significant association was present in women in premenopausal age.
Histosections were routinely stained with H and E, p53
immunostaining were also done on the same specimens.
Recent studies have shown that S100B interacts directly with P53
protein and binds to its trans-activation domain as well as its C terminal end, which results in decrease in the P53
level and loss of its tumour suppressing activity.
The report reviews Cellular Tumor Antigen P53
(Tumor Suppressor P53
or Antigen NY-CO-13) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
A lot of Ehrlich carcinoma cells expressed both p53
& Caspase 3 and present predominantly in large blood vessels central veins and less in sinusoids and periportal areas.
Antibodies against cytokeratin 18, p53
upregulated modulator of apoptosis- (PUMA-) [alpha], B-cell lymphoma- (Bcl-) 2, Bcl-2-associated X protein (Bax), and a SIRT1 activity assay kit were obtained from Abcam (Cambridge, UK).
Caffeine represses p53
target gene expression in RT4 cells exposed to ionizing radiation
Apoptosis induction often appears to be related to the production process of P53
For GST pull-down assay (17), 50 [micro]g of GST- WT p53
or GST proteins was mixed with 5 mg of either the MCF7 or MDA-MB-468 cell lysates for 2 hr at 4[degrees]C.
The summary of immuno-staining data and staining intensity of p53
and KI-67 according to LI in Normal, dysplastic and malignant cases is given in Table No 3 and 4 respectively.
In this study, the level of serum p53
in chronic hepatitis and cirrhotic patients following HBV infection is evaluated.