pancreas (redirected from pancreas disease)

pancreas (păn`krēəs), glandular organ that secretes digestive enzymes and hormones. In humans, the pancreas is a yellowish organ about 7 in. (17.8 cm) long and 1.5 in. (3.8 cm) wide. It lies beneath the stomach and is connected to the small intestine at the duodenum (see digestive system). Most of the pancreatic tissue consists of grapelike clusters of cells that produce a clear fluid (pancreatic juice) that flows into the duodenum through a common duct along with bile from the liver. Pancreatic juice contains three digestive enzymes: tryptase, amylase, and lipase, that, along with intestinal enzymes, complete the digestion of proteins, carbohydrates, and fats, respectively. Scattered among the enzyme-producing cells of the pancreas are small groups of endocrine cells, called the islets of Langerhans, that secrete two hormones, insulin and glucagon. The pancreatic islets contain several types of cells: alpha-2 cells, which produce the hormone glucagon; beta cells, which manufacture the hormone insulin; and alpha-1 cells, which produce the regulatory agent somatostatin. These hormones are secreted directly into the bloodstream, and together, they regulate the level of glucose in the blood. Insulin lowers the blood sugar level and increases the amount of glycogen (stored carbohydrate) in the liver; glucagon has the opposite action. Failure of the insulin-secreting cells to function properly results in diabetes, which can occur in two major forms, the division being between juvenile onset and onset in maturity.

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pancreas

Compound gland functioning as both an exocrine (secreting through a duct) and an endocrine (ductless) gland. It continuously secretes pancreatic juice (containing water, bicarbonate, and enzymes needed to digest carbohydrates, fat, and protein) through the pancreatic duct to the duodenum. Scattered among the enzyme-producing cells are the islets of Langerhans, which secrete insulin and glucagon directly into the bloodstream. Disorders include inflammation (pancreatitis), infections, tumours, and cysts. If more than 80–90% of the pancreas must be removed, the patient will need to take insulin and pancreatic extracts. See also diabetes mellitus; hypoglycemia.