papaverine


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papaverine

(pəpăv`ərēn), alkaloid found in opiumopium,
substance derived by collecting and drying the milky juice in the unripe seed pods of the opium poppy, Papaver somniferum. Opium varies in color from yellow to dark brown and has a characteristic odor and a bitter taste.
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 that acts as a muscle relaxant and vasodilator. The drug relaxes the smooth muscle of the larger blood vessels and is used to increase the blood supply to the brain or to the heart, as in the treatment of angina pectorisangina pectoris
, condition characterized by chest pain that occurs when the muscles of the heart receive an insufficient supply of oxygen. This results when the arteries that supply the heart muscle with oxygenated blood are narrowed by arteriosclerosis.
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. It is also used in the treatment of some types of blood clot formation and in the treatment of impotence when the condition is caused by a lack of blood flow.

Papaverine

 

an antispasmodic alkaloid that is found in opium. Papaverine is also produced synthetically. It is used in solutions and tablets for treating such spastic conditions as hypertension, angina pectoris, and irritable colon.

papaverine

[pə′pav·ə‚rēn]
(organic chemistry)
C20H21O4N A white, crystalline alkaloid, melting at 147°C; soluble in acetone and chloroform, insoluble in water; used as a smooth muscle relaxant and weak analgesic, usually as the water-soluble hydrochloride salt.
References in periodicals archive ?
Nevertheless, an intolerance to vincamine and papaverine chlorhydrate could not be excluded, as the safety of these drugs has not been studied in birds.
These metabolism results were consistent with the previous plant cell transformation studies on papaverine and isopapaverine.
Attenuation of the no-reflow phenomenon after coronary angioplasty for acute myocardial infarction with intracoronary papaverine.
Papaverine has a short duration of effect and is less commonly used now because it is associated with a reduction in brain oxygen tension, an increase in ICP (particularly when multiple arterial segments are treated) (51) and neurological deterioration related to a permanent neurotoxic effect (52).
Functional characterization of a novel benzylisoquinoline O-methyltransferase suggests its involvement in papaverine biosynthesis in opium poppy (Papaver somniferum L).
Agents that affect the adenylate cyclase/cyclic AMP (AC/cAMP) signal-transduction pathway included 3-isobuty1-1-methylxanthine (IBMX), the-ophylline, papaverine.
It has narcotic, soporific, analgesic and astringent effects, and contains approximately 1% morphine, as well as codeine, papaverine and other alkaloids.
This is done during maximal blood flow (hyperemia), which can be induced by injecting products such as adenosine or papaverine.
One of the major component in the wood of Cedrus deodara, himachalol, has antispasmodic and spasmolytic activities similar to those of papaverine that also induces spasm in different tissues such as ileum, jejunum and bronchial muscles when given in different doses (Kar et al.
1 H - ++ DC + +++ A-Mt NE NE Phenax H - - rugosus DC - - A-Mt NE NE Standards Papaverine Taxol +++ +++ Family Species Phytocompounds Flavonoids Tannins Saponins Apocynaceae Mandevilla - +++ +++ veraguensis - +++ +++ +++ +++ + Blepharodon - - +++ mucronatum +++ - +++ +++ ++ + Mandevilla - - +++ fendleri - + +++ - - - Cactaceae Rhipsalis - - ++ micrantha - - ++ - - ++ Costaceae Costus sp.
Many vasodilator agents such as papaverine, Ca antagonists, phosphodiesterase inhibitor- milrinone, phenoxybenzamine and verapamil-nitro-glycerine, verapamil-papaverine solutions are used overcome the spasm.
Alkaloids make up about 10% of the dried poppy latex of which morphine, codeine, thebaine and papaverine are the most important with morphine as the principal alkaloid (Van Wyk et al.