paraldehyde


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paraldehyde

(pârăl`dəhīd'), nervous system depressantdepressant,
any one of various substances that diminish functional activity, usually by depressing the nervous system. Barbiturates, sedatives, alcohol, and meprobamate are all depressants. Depressants have various modes of action and effects.
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 similar to alcohol in its effects and used as a sedativesedative,
any of a variety of drugs that relieve anxiety. Most sedatives act as mild depressants of the nervous system, lessening general nervous activity or reducing the irritability or activity of a specific organ.
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. A colorless flammable liquid with a disagreeable odor, paraldehyde produces sleep for up to 12 hr. with little or no muscle, heart, or respiratory depression. It is often given to alcoholics having delirium tremens, to induce sleep, and is also used to calm psychiatric patients. Like alcohol and other depressants it is addictive (see drug addiction and drug abusedrug addiction and drug abuse,
chronic or habitual use of any chemical substance to alter states of body or mind for other than medically warranted purposes. Traditional definitions of addiction, with their criteria of physical dependence and withdrawal (and often an underlying
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). Paraldehyde is also used in the manufacture of synthetic resins, as a preservative, and in preparing leather. It is produced by treating acetaldehyde with a small amount of sulfuric acid.

Paraldehyde

 

a trimer of acetaldehyde. Colorless liquid, boiling point 1240C. The structure of paraldehyde is

The compound readily depolymerizes upon heating with a small quantity of sulfuric acid, and is thus a convenient storage form of acetaldehyde. Paraldehyde exhibits a weak narcotic effect.

paraldehyde

[pə′ral·də‚hīd]
(organic chemistry)
C6H12O3 Acetaldehyde polymer; colorless, flammable, toxic liquid, miscible with most organic solvents, soluble in water; melts at 12.6°C, boils at 124.5°C; used as a chemical intermediate, in medicine, and as a solvent.
References in periodicals archive ?
I had one patient on a 12 hour flight from Hawaii to the US who had not been sufficiently sedated before the flight, but soon began to utter obscenities loudly for most of the flight, even after I gave him a paraldehyde injection (the protocol recommended for the most extreme situation).
paraldehyde for her as a massaging gel, which smelt strongly of
domesricus is suggested by earlier work showing that ovariectomy results in a decrease in the amount of paraldehyde fuchsin (PAF) positive material in the PIC and decreased levels of several PAF positive polypeptides in the brain and corpora cardiaca (Bradley and Simpson, 1981).
Pharmacokinetics and clinical use of parenteral phenytoin, phenobarbital, and paraldehyde.
For some reason, the Queen Street psychiatrists prescribed a lot of paraldehyde to Davis, as well as Nozinan and Valium.
In the late 19th century, chloral hydrate and paraldehyde, with characteristics similar to alcohol, were introduced into medical practice as sedatives.