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An acute or chronic disease of the skin characterized by the appearance of bullae, which develop in crops or in continuous succession.



a chronic disease characterized by a crop of blisters, or bullae, having a flaccid covering and serous-hemorrhagic contents; the blisters form on the apparently intact skin or mucosa of the oral cavity, larynx, eyes, and genitals. The blisters rapidly enlarge and multiply, bursting to form extensive ulcerated surfaces. The patient’s general condition is disturbed; there is general weakness and elevation of body temperature. Infection of the mouth and larynx makes food intake difficult.

The causes of pemphigus have not been conclusively determined. The disease usually afflicts middle-aged and elderly persons. The mechanism of formation of pemphigus vulgaris is acantholysis, a type of degenerative change in epidermal cells. It involves the dissolution of the intercellular bridges, degenerative change of the nuclei, and loss of part of the cell protoplasm. As a result, communication between the layers of epidermis is disrupted. In other forms of pemphigus, the blisters form as a result of an inflammatory process.

Pemphigus vulgaris progresses gradually, and cachexia develops. The prognosis for persons suffering from other forms of pemphigus is relatively favorable. Treatment includes the ingestion of hormonal preparations, antimicrobial agents, or analgesics. Disinfecting solutions may be applied externally.


References in periodicals archive ?
Clinical and histopathological features of pemphigus foliaceus with and without eosinophilic infiltrates: a retrospective evaluation of 40 dogs.
In contrast, pemphigus foliaceus cases showed immunoreactivity for IgG4 in the intercellular junctions of superficial keratinocytes, reflecting the known location of desmoglein 1 (Figure 1, C).
The Akita, Chow Chow, Dachshund, Bearded Collie, Doberman Pinscher, Schipperke, Finnish Spitz, and Newfoundland are most commonly affected by pemphigus foliaceus, which usually develops on the head and feet before sometimes spreading to more of the body.
Bastuji-Garin S, Souissi R, Blum L, et al: Comparative pidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tnisian women.
Endemic pemphigus foliaceus in Venezuela: Report of two children.
The Foundation focuses on the three main types of pemphigus, which vary in severity: pemphigus vulgaris, the most common, pemphigus foliaceus, the least severe, and paraneoplastic pemphigus, the least common and most severe.
Our study demonstrated that the frequency of diagnosis of skin bullous lesions in city of Sari is almost similar to other related studies and the most common diagnoses are pemphigus vulgaris, bullous pemphigoid, dermatitis herpetiformis and pemphigus foliaceus.
The differential diagnosis include, Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) or drug-induced pemphigus foliaceus.
Additionally, the study included a convenience sample of 80 healthy patients with no epidemiological history of leishmaniasis, 24 patients with Chagas disease, 13 patients with American pemphigus foliaceus, 8 patients with lepromatous leprosy, 9 patients with deep mycosis, 16 VRDL-positive patients at a minimum dilution of 1:8, and 33 patients with rheumatic disease who were positive for at least one rheumatic marker test, including anti-streptolysin O (ASO), C-reactive protein (CRP), and rheumatoid factor (RF).
Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR: Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.