Pemphigus

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Related to pemphigus vulgaris: pemphigus foliaceus

pemphigus

[′pem·fə·gəs]
(medicine)
An acute or chronic disease of the skin characterized by the appearance of bullae, which develop in crops or in continuous succession.

Pemphigus

 

a chronic disease characterized by a crop of blisters, or bullae, having a flaccid covering and serous-hemorrhagic contents; the blisters form on the apparently intact skin or mucosa of the oral cavity, larynx, eyes, and genitals. The blisters rapidly enlarge and multiply, bursting to form extensive ulcerated surfaces. The patient’s general condition is disturbed; there is general weakness and elevation of body temperature. Infection of the mouth and larynx makes food intake difficult.

The causes of pemphigus have not been conclusively determined. The disease usually afflicts middle-aged and elderly persons. The mechanism of formation of pemphigus vulgaris is acantholysis, a type of degenerative change in epidermal cells. It involves the dissolution of the intercellular bridges, degenerative change of the nuclei, and loss of part of the cell protoplasm. As a result, communication between the layers of epidermis is disrupted. In other forms of pemphigus, the blisters form as a result of an inflammatory process.

Pemphigus vulgaris progresses gradually, and cachexia develops. The prognosis for persons suffering from other forms of pemphigus is relatively favorable. Treatment includes the ingestion of hormonal preparations, antimicrobial agents, or analgesics. Disinfecting solutions may be applied externally.

S. S. KRIAZHEVA

References in periodicals archive ?
This global, multicentre, randomised, double-blind, placebo-controlled, parallel-group study (OPV116910) will assess the efficacy, safety, and tolerability of subcutaneous ofatumumab in subjects with pemphigus vulgaris.
A review of the Pemphigus Vulgaris products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
In pemphigus vulgaris cases, the immunoreactivity for IgG4 was most condensed to the intercellular junctions of suprabasal keratinocytes, consistent with the known location of desmoglein 3 (Figure 1, A).
At baseline, all patients with pemphigus vulgaris were corticosteroid dependent and other systemic immunosuppressive agents were contraindicated.
The pathology differential diagnosis for lichen planus includes mucous membrane pemphigoid, pemphigus vulgaris, lichenoid reaction to drugs, lupus erythematosus, chronic graft-versus-host disease, linear IgA disease, and cinnamon-induced stomatitis.
Pemphigus vulgaris in pregnancy: analysis of current data on the management and outcomes.
Histologically, the acantholysis seen in Grover disease occurs in a variety of different patterns in small, circumscribed foci resembling Darier-White disease, pemphigus vulgaris, pemphigus foliaceous, Hailey-Hailey disease, and a spongiotic dermatitis.
Pemphigus vulgaris is part of a group of chronic blistering skin diseases in which autoantibodies are directed against distinct antigens on the cell surface of keratinocytes, resulting in loss of cell adhesion (acantholysis) (1).
Peptimmune has one product in clinical trials for the treatment of pemphigus vulgaris, and a pipeline of late stage preclinical products for the treatment of autoimmune and metabolic diseases including, multiple sclerosis, rheumatoid arthritis and obesity.
Pemphigus vulgaris is one of a group of autoinunune disorders that are caused by autoantibodies against the desmoglein adhesion molecules of squamous epithelial cells.
1, Medicare will start covering IVIg treatments for certain mucocutaneous blistering diseases, including pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita.
Global Markets Direct's, 'Pemphigus Vulgaris - Pipeline Review, H1 2012', provides an overview of the Pemphigus Vulgaris therapeutic pipeline.