Pemphigus

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Related to pemphigus vulgaris: pemphigus foliaceus

pemphigus

[′pem·fə·gəs]
(medicine)
An acute or chronic disease of the skin characterized by the appearance of bullae, which develop in crops or in continuous succession.

Pemphigus

 

a chronic disease characterized by a crop of blisters, or bullae, having a flaccid covering and serous-hemorrhagic contents; the blisters form on the apparently intact skin or mucosa of the oral cavity, larynx, eyes, and genitals. The blisters rapidly enlarge and multiply, bursting to form extensive ulcerated surfaces. The patient’s general condition is disturbed; there is general weakness and elevation of body temperature. Infection of the mouth and larynx makes food intake difficult.

The causes of pemphigus have not been conclusively determined. The disease usually afflicts middle-aged and elderly persons. The mechanism of formation of pemphigus vulgaris is acantholysis, a type of degenerative change in epidermal cells. It involves the dissolution of the intercellular bridges, degenerative change of the nuclei, and loss of part of the cell protoplasm. As a result, communication between the layers of epidermis is disrupted. In other forms of pemphigus, the blisters form as a result of an inflammatory process.

Pemphigus vulgaris progresses gradually, and cachexia develops. The prognosis for persons suffering from other forms of pemphigus is relatively favorable. Treatment includes the ingestion of hormonal preparations, antimicrobial agents, or analgesics. Disinfecting solutions may be applied externally.

S. S. KRIAZHEVA

References in periodicals archive ?
Included in this group is pemphigus vulgaris (PV), a bullous disease involving the skin and mucous membranes, which may be fatal if not treated with appropriate immunosuppressive agents.
Oral pemphigus vulgaris clinic-pathological follow-up of 34 cases.
This global, multicentre, randomised, double-blind, placebo-controlled, parallel-group study (OPV116910) will assess the efficacy, safety, and tolerability of subcutaneous ofatumumab in subjects with pemphigus vulgaris.
Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris.
Pemphigus vulgaris is a painful, and, if neglected, a potentially life-threatening blistering disease.
Disease progression from mucosal to mucocutaneous involvement in a patient with desquamative gingivitis associated with pemphigus vulgaris.
Identify and understand important and diverse types of therapeutics under development for Pemphigus Vulgaris.
Pemphigus vulgaris is a potentially life-threatening autoimmune mucocutaneous disease.
We searched our pathologic archive and retrieved 18 specimens of pemphigus from 15 patients, including 12 cases of pemphigus vulgaris and 6 of pemphigus foliaceus.
1) There have also been a few published reports of various unusual ophthalmic presentations of herpetic infection: recurrent HSV eyelid infection, (2) herpetic meibomianitis, (3) herpetic-associated refractory (to corticosteroids) pemphigus vulgaris involving the eyelids, (4) as well as other lesions simulating neoplasia in the genital and peri-anal areas.
Pemphigus vulgaris (PV) is a rare cutaneous autoimmune disorder that manifests as flaccid blisters and erosions in the skin and mucous membranes.
Desmoglein 3 protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.