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penetrance |
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penetrance [′pen·ə·trəns] (genetics) The proportion of individuals carrying a dominant gene in the heterozygous condition or a recessive gene in the homozygous condition in which the specific phenotypic effect is apparent. Also known as gene penetrance. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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4) The disease may be inherited as an autosomal-dominant trait with variable penetrance in 50% of patients, or it may occur as a result of a spontaneous mutation. The fourth gene has a penetrance of nearly 100 percent, but the disease may not show up until age 80. Interaction between genetic susceptibility and early life environmental exposure determines tumor suppressor gone penetrance. |
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