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penicillinase |
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penicillinase [‚pen·ə′sil·ə‚nās] (biochemistry) A bacterial enzyme that hydrolyzes and inactivates penicillin. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Postulated resistance mechanisms include overproduction of conventional penicillinases, production of an inducible, plasmid-mediated, membrane-bound methicillinase, and in some cases, point mutations of penicillin-binding-proteins (4). Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Extended-spectrum [beta]-lactamase agents are point mutants of "old" penicillinases (23). |
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