penicillinase

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Related to penicillinases: cephalosporinase

penicillinase

[‚pen·ə′sil·ə‚nās]
(biochemistry)
A bacterial enzyme that hydrolyzes and inactivates penicillin.
References in periodicals archive ?
Staphylococcal resistance to penicillin is mediated by penicillinase (a form of [beta]-lactamase) production: an enzyme that cleaves the P-lactam ring of the penicillin molecule, rendering the antibiotic ineffective.
To the Editor: Class D OXA [beta]-lactamases are characterized as penicillinases that can hydrolyze oxacillin and cloxacillin and are poorly inhibited by clavulanic acid and EDTA.
TEM-3 [beta]-lactamases which hydrolyzes broad-spectrum cephalosporins, is derived from the TEM-2 penicillinases by two amino acid substitutions.
Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Enterobacteriaceae, except Salmonella and Klebsiella) Group 2 penicillinases D Staphylococcal A penicillinases;TEM-1, TEM-2, SHV-1 (broadspectrum); TEM and SHV variants (e.
Postulated resistance mechanisms include overproduction of conventional penicillinases, production of an inducible, plasmid-mediated, membrane-bound methicillinase, and in some cases, point mutations of penicillin-binding-proteins (4).

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