peptide synthetase


Also found in: Medical.

peptide synthetase

[′pep‚tīd ′sin·thə‚tās]
(biochemistry)
A ribosomal synthetase that catalyzes the formation of peptide bonds during protein synthesis.
References in periodicals archive ?
It was proposed that a polyketide synthase (PKS) catalyzes the condensation of a chlorobutanoyl intermediate with an acetate unit, and subsequently with the clyclohexenyl-alanine amino acid arising from the shikimate pathway which is incorporated into the product by the activity of a non-ribosomal peptide synthetase (NRPS).
Microcystin is a hepatotoxin produced by a non-ribosomal pathway through a polyketide synthase/non-ribosomal peptide synthetase (PKS/NRPS) complex known as microcystin synthetase, which is responsible for the incorporation of amino acids in the peptide chain (Kleinkauf and von Dohren, 1996; Dittmann et al.
They are synthesized by non-ribosomal peptide synthetases (NRPSs), a diverse group of large multifunctional enzymes that operate as molecular assembly lines.
The BB and many of the siderophores are produced non-ribosomally by large, multi-domain enzymes termed as non-ribosomal peptide synthetases (NRPS) that can assemble peptides of wide structural diversity and broad biological activity [16].