perforin


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perforin

[′pər·fər·ən]
(immunology)
An enzyme that is secreted by natural killer cells and cytotoxic T cells and destroys foreign cells by puncturing their membranes, causing leakage of the cell contents. Also known as cytolysin; pore-forming protein.
References in periodicals archive ?
The new research confirmed that the important parts of the perforin molecule are quite similar to those in toxins deployed by bacteria such as anthrax, listeria and streptococcus.
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways.
It inactivates CD8+ T cells and inhibits the release of perforin, granzyme and granulysin in addition to blocking the proapoptotic NF-kB pathway.
Hucre-iliskili toksisitede yer alan (granzim, perforin gibi) genlerde (CD3+CD8+ T hucre) "upregulation" vardir.
Primary or familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessive disorder of immune dysfunction caused by mutations in Perforin, Munc 13-4, Syntaxin 11 and STBX2 genes (2-5).
CD8+ CTL from lungs of Mycobacterium tuberculosis infected mice express perforin in vivo and lyse infected macrophages.
Working with Trend Micro since 1996, Joe has been involved with anti-virus research since 1992, having studied and created detection and disinfection for thousands of viruses, including work with Perforin Antivirus and VDSARG (Virus Detection System Advanced Research Group).
Subcutaneous panniculitis-like T-cell lymphoma is typically positive for TIA1, granzyme B, and perforin.
In previous studies from our country, it was reported that the perforin gene W374X mutation was responsible for familial HLH cases presenting within six months of life.
Thus, the RIBA could induce hypothyroidism by Th1-dependent activation of CD8+ T lymphocytes which induce cellular destruction predominantly by the perforin pathway [47].