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perforin |
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perforin [′pər·fər·ən] (immunology) An enzyme that is secreted by natural killer cells and cytotoxic T cells and destroys foreign cells by puncturing their membranes, causing leakage of the cell contents. Also known as cytolysin; pore-forming protein. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Lysis of infected epithelial cells is mediated by exocytosis granules containing perforin and granzymes (18,19). Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity. Perforin helps the cell-killing compounds gain entry to target cells, Connors says. |
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