Perfusion

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perfusion

[pər′fyü·zhən]
(physiology)
The pumping of a fluid through a tissue or organ by way of an artery.

Perfusion

 

a method of passing physiological solutions, blood, blood substitutes, or other fluids through the blood vessels of an organ, a part of the body, or the entire body. Perfusion may be performed on organs completely removed from the body or on organs within the body but isolated from the general vascular system. Widely used in experimental physiology, it permits preservation of the vital activities of organs for a certain period, enabling the study of organ functions and of the effect of hormones, mediators, enzymes, and medicinal substances on physiological systems and the entire body. The method is used in various branches of surgery, including transplantation of organs and tissues. Perfusion of the entire body is used, for example, during heart surgery.

The term “perfusion” also designates the supplying of blood to organs of the body under natural conditions (for example, perfusion of the kidneys, brain, or other organs), which is determined by the state of cardiac activity and local vascular tonus.

References in periodicals archive ?
We are excited about the prospect of what this ex vivo, out-of-the-body perfusion technique could mean for our many transplant candidates who often spend years waiting for lungs to become available," says the principal investigator, Bartley P.
Organ Recovery Systems develops advanced perfusion techniques to improve the quality and quantity of organs, tissues and cells for transplantation.
As compared to current cold storage or cold perfusion techniques, the Organ Care System may allow the organ to withstand longer periods of time outside of the body and experience less damage resulting from lack of blood supply to the organ during transportation to the recipient.
Moreover, the 15 centimeter coverage is offered in the entire field-of-view, unlike other perfusion techniques offered on large-area detectors where large cone-beam angle impacts the volume that can be visualized.
Organ Recovery Systems is organized into three operating groups: the Perfusion Services Group helps leading transplant centers and organ procurement organizations (OPOs) by employing proprietary perfusion techniques for evaluation and therapy of traditional, expanded criteria, and nonheartbeating donor kidneys prior to transplant; the Medical Devices Group develops perfusion-based devices to improve the preservation, assessment, and treatment of organs for transplantation; and the Charleston Research Center develops new technologies for cell and tissue preservation and evaluation while conducting basic and applied research to support the company's platform of organ therapy products.
The company is organized into three operating groups: the Perfusion Services Group helps leading transplant centers and organ procurement organizations (OPOs) by employing proprietary perfusion techniques for evaluation and therapy of traditional, expanded criteria, and nonheartbeating donor kidneys prior to transplant; the Medical Devices Group develops perfusion-based devices to improve the preservation, assessment, and treatment of organs for transplantation; and the Charleston Research Center develops new technologies for cell and tissue preservation and conducts basic and applied research to support the company's platform of organ therapy products.