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acetophenetidin
(redirected from phenacetin)

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.03 sec.
acetophenetidin [‚as·ə‚tä·fə′net·ə‚din]
(pharmacology)
CH3CONHC6H4OC2H5Odorless, white crystals or powder with a melting point of 135°C; soluble in alcohol, chloroform, and ether; used as an analgesic.


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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
Phenacetin - no longer available in many countries, including the United States - bears a strong chemical resemblance to acetaminophen, and some scientists say phenacetin's dangers hint at possible hidden risks for chronic users of its still-opular analgesic cousin.
Other risk factors include exposure to asbestos, cadmium, or gasoline, and the use of certain pain medications containing phenacetin.
 
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