phosphofructokinase


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phosphofructokinase

[‚fäs·fə‚fru̇k‚tō′kī‚nās]
(biochemistry)
A glycolytic enzyme that functions in carbohydrate metabolism by catalyzing the phosphorylation of fructose phosphate.
References in periodicals archive ?
Effects of insulin and actin on phosphofructokinase activity and cellular distribution in skeletal muscle.
Phosphofructokinase activity and acidosis during short-term tetanic contractions.
8] and validated with data for glycolytic oscillations involving phosphofructokinase in the skeletal muscle [9].
In addition to direct phosphorylation effects on key metabolic targets like acetyl CoA carboxilase (ACC--committed step in fatty acid synthesis) and phosphofructokinase 2 (PKF2--master regulator of glycolysis) (29), activation of AMPK also leads to inhibition of the mammalian target of rapamycin (mTOR) (30) which in turn can decrease signaling through the kinase Akt, and reduce the efficiency of protein synthesis via decreased phosphorylation of mTOR targets 4EBP-1 and S6K, essential components of the cap-dependent translation machinery (31, 32).
Fructose-l,6-bis phosphatase, phosphofructokinase and glucose-6- phosphate dehydrogenase from fermenting and non fermenting yeasts.
It has been suggested that more severe illness may develop in English springer spaniels with suspected phosphofructokinase deficiency and persons with glucose 6-phosphate dehydrogenase deficiency when infected with R.
Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes.
Experimental studies have shown that many glycolytic enzymes bind cytoskeletal proteins reversibly including lactate dehydrogenase (LDH), fructose-1,6-bisphosphate aldolase (aldolase), glyceraldehydes 3-phosphate dehydrogenase (GAPDH), 3-phosphoglycerate kinase, glucose isomerase, phosphofructokinase, and pyruvate kinase (3,4) and that the interaction may be electrostatic in nature (3).
Tarui's disease is a rare inborn error of metabolism involving a deficiency of the muscle isozyme of phosphofructokinase (PFK).
We have also reported that phosphofructokinase (PFK) is present on that same calcium-regulatory subfraction of pn-ER (which we designated as subfraction B; 2, 5).
Skeletal muscle glycolytic capa-city and phosphofructokinase regulation in horses with polysaccharide storage myopathy.
The intrinsic fluorescence of Bacillus stearo-thermophilus phosphofructokinase (BsPFK) is not sensitive to ligand binding.

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