Timbrell, Determination of Hydralazine Metabolites: 4-hydrazino-phthalazin-1-one and N-acetylhydrazinophthalazin-1-one by Gas Chromatography and S-Triazolo[3,4-alpha] phthalazine
and phthalazinone by High-Performance Liquid Chromatography.
The search for multicomponent reaction has paved a considerable attention for the use of phthalazine
derivatives which has gained importance during recent year, which may be attributed to their wide range of pharmacological and biological activities .
These alkaloids include quinazoline, quinaxaline, cinnoline, phthalazine
and other three or four membered ring azaheterocycles such as, pteridine, alloxazine, isoalloxazine .